Sun, Xiu-rong published the artcileObservation on analgesic effect of parecoxib sodium on patients undergoing subtotal thyroidectomy, Formula: C19H17N2NaO4S, the publication is Shiyong Yaowu Yu Linchuang (2016), 19(5), 599-601, database is CAplus.
To discuss the analgesic effect of parecoxib sodium on patients who have undergone subtotal thyroidectomy. The clin. data of 105 cases who had undergone subtotal thyroidectomy in our hospital from Nov. 2014 to Nov. 2015 were collected. The patients were given i.v. injection of parecoxib sodium (40 mg) 15 min before the end of operation (group A). The patients were given i.v. injection of parecoxib sodium (40 mg) immediately after patients returned to the wards (B group). The patients were given i.v. injection of NS (2 mL) solution 15 min before the end of operation (group C). Each group included 35 cases. The visual simulation pain score (VAS score) at 0, 2, 4, 6, 12, and 24 h after returning to the ward, postoperative analgesia satisfaction rate 1 d after operation and the incidence of side effects of the three groups were observed and compared. The VAS scores of A and B groups at each time point were significantly lower than that of C group, with statistically significant difference (P < 0.05). The VAS scores of A group (0, 2 h) were lower than those of B group, with statistically significant difference (P < 0.05). The postoperative occurrence rate of side effects of the three groups had no statistical significance (P > 0.05). Application of parecoxib during or after thyroid subtotal surgery can reduce postoperative pain and increase satisfaction of analgesic effect. Moreover, application of parecoxib is safe and reliable. Giving i.v. injection of parecoxib sodium 15 min before the end of surgery is a better choice.
Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H5ClN2S, Formula: C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem