Song, Jie published the artcileEffect of parecoxib sodium on inflammatory mediator and postoperative cognitive dysfunction after laparoscopic surgery in elderly patients, Synthetic Route of 198470-85-8, the publication is Guoji Mazuixue Yu Fusu Zazhi (2015), 36(6), 493-495, 501, database is CAplus.
The effects of parecoxib Na on inflammatory mediator and postoperative cognitive dysfunction (POCD) after laparoscopy surgery in elderly patients were studied. Eighty ASA patients phys. status I or II of both sexes, aged over 65 yr, weighing 45-70 kg, undergoing laparoscopic cholecystectomy, were randomly divided into parecoxib Na (group P, n=40) and control groups (group C, n=40). The patients in group P were given i.v. parecoxib 40 mg before induction of anesthesia. Ones in group C were given equal volume normal saline instead of parecoxib. Neuropsychol. testing was performed with mini-mental state examination (MMSE) on the preoperative day, 1st and 3rd postoperative day. Venous blood samples were collected before induction of anesthesia (T0), immediately after skin incision (T1), 30 min after CO2 pneumoperitoneum (T2), at the end of operation (T3), the first day of operation (T4), the third day of operation(T5) for determination of serum concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assay (ELISA). The development of POCD was recorded within 3 days after surgery. Compared with preoperative 24 h [group C (28.2±1.2), group P (28.8±1.0)], the MMSE scores of resting in group C and group P were significantly reduced [(23.0±2.5), (25.0±2.8)] (P<0.05). The MMSE scores of resting in group P were more than those in group C [(25.0±2.8) vs (23.0±2.5)] (P<0.05). The development of POCD within 72 h was less than that in group C (P<0.05). Compared with group C, the serum concentrations of TNFa [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] and IL-6 [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] at T3-T5 were significantly decreased in group P (P<0.05). Compared with T0, the serum concentrations of TNF-α and IL-6 at T3-T5 were increased in two group (P<0.05). Parecoxib Na might decrease the development of POCD in elderly patients undergoing laparoscopic cholecystectomy by inhibition of inflammatory responses.
Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H6O3, Synthetic Route of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem