Category: 53983-15-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53983-15-6,Ethyl 5-amino-4-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.,53983-15-6

5-amino-obtained Example 2 The 4-phenyl-isoxazole-3-carboxylic acid ethyl ester A1 (0.464g, 2mol), benzaldehyde(0.212g, 2mol) and 10mL absolute ethanol, was added one drop of concentrated sulfuric acid as a catalyst, was heated to reflux, TLC monitoring of the reaction,After completion of the reaction, cooled to room temperature, suction filtered, washed with water and purified by column chromatography to give a white powdery solid 0.45g. Yield 71.77%.

As the paragraph descriping shows that 53983-15-6 is playing an increasingly important role.

Reference£º
Patent; Shenyang Pharmaceutical University; Xu, Wei; Chen, Yu; Zhang, Rui; (15 pag.)CN105777661; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

53983-15-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53983-15-6,Ethyl 5-amino-4-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

5.0 g (23 mmol) of ethyl phenylcyanopyruvate were reacted according to the method described in Chem. Ber. 107 (1974) 2794-2795 and Ber. Deutsch. Chem. Ges. 33 (1900) 2592-2595. Whereby there was obtained in 69.7% yield ethyl 5-amino-4-phenyl-3-isoxazolecarboxylate as beige crystals which melted at 119-121 after recrystallization from ethyl acetate/hexane. 2.9 g (12.5 mmol) of ethyl 5-amino-4-phenyl-3-isoxazolecarboxylate were heated to 110 for 2 hours under reduced pressure with 5.0 g (31.2 mmol) of t-butyl (2-aminoethyl)carbamate, whereby the ethanol formed was distilled off continuously. The cooled reaction mixture was dissolved in methylene chloride and chromatographed on 100 g of silica gel. Elution with methylene chloride which contains 5%. 10% and, respectively, 20% of ethyl acetate, combining of the pure fractions and evaporation yielded 1.9 g of crystals. Recrystallization from ethyl acetate/hexane yielded 1.5 g (34.7%) of t-butyl [2-(5-amino-4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate as white crystals, melting point 144.

The synthetic route of 53983-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US5011849; (1991); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

53983-15-6, Ethyl 5-amino-4-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53983-15-6, EXAMPLE 14 5.0 % (15.1 mmol) of t-butyl [2-(4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate were stirred at room temperature for 16 hours with trifluoroacetic acid analogously to Example 13. After concentration there was obtained a residue which was converted into the hydrochloride. Recrystallization of the crude product from methanol/ether yielded 3.B g (94.1%) of N-(2-aminoethyl)4-phenyl-3-isoxazolecarboxamide hydrochloride as white crystals, melting point 211-212. The t-butyl [2-(4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate used as the starting material was prepared as follows: In an analogous manner to that described in J. Org. Chem. 50 (13) 1985, 2372-2375, 7.6 g (32.72 mmol) of ethyl 5-amino-4-phenyl-3-isoxazolecarboxylate in 160 ml of glacial acetic acid, 50 ml of water and 80 ml of tetrahydrofuran were treated portionwise at 15-20 while stirring within 1 hour with a total of 22.6 g of sodium nitrite. The reaction mixture was thereafter poured into 1 liter of water and extracted 3 times with 400 ml of methylene chloride each time. The organic phases were combined and first washed twice with 1 liter of saturated sodium bicarbonate solution each time and then once with 1 liter of water, dried, filtered and concentrated in a vacuum, whereby after chromatography on silica gel and elution with methylene chloride there were obtained 3.9 g (55%) of ethyl 4-phenyl-3-isoxazolecarboxylate as a yellow oil which was used without further purification.

53983-15-6 Ethyl 5-amino-4-phenylisoxazole-3-carboxylate 4962898, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Hoffmann-La Roche Inc.; US5011849; (1991); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem