Category: 84746-24-7

Electric Literature of C12H14N6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Synthesis of linked heterocycles mediated by high pressure SNAr reactions. Author is Matsumoto, Kiyoshi; Hashimoto, Shiro; Minatogawa, Hiroyuki; Munakata, Megumu; Otani, Sinichi.

A series of linked heterocycles involving piperazine and aromatic five- and six-membered heterocycles were prepared in 48-100% yields by SNAr reactions of piperazine with halo heteroaromatics under high pressure.

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Isoxazole – Wikipedia,
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Application of 84746-24-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Synthesis of linked heterocycles mediated by high pressure SNAr reactions. Author is Matsumoto, Kiyoshi; Hashimoto, Shiro; Minatogawa, Hiroyuki; Munakata, Megumu; Otani, Sinichi.

A series of linked heterocycles involving piperazine and aromatic five- and six-membered heterocycles were prepared in 48-100% yields by SNAr reactions of piperazine with halo heteroaromatics under high pressure.

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Isoxazole – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Analysis of new serotonergic anxiolytics by liquid chromatography, the main research direction is serotonergic anxiolytic determination liquid chromatog; HPLC serotonergic anxiolytic determination.Related Products of 84746-24-7.

A simple isocratic procedure was developed for the anal. of new serotonergic anxiolytics and related compounds in bulk, pharmaceuticals, and in biol. samples. The system may be applied for the assay of other serotonergic anxiolytics of related structure such as buspirone. The HPLC assay utilized a reversed-phase C18 column, a mobile phase consisting of a mixture (55:45) of (A) buffer potassium dihydrogen phosphate (0.05M) containing sodium lauryl sulfate (0.005M) and (B) MeCN. A fluorescence detection was used with λex 237 nm; λem 374 nm. The accuracy, precision and sensitivity of the proposed method were established. Standard curves were linear with respect to concentration in the range 0.05-7.5 μg mL-1. The method also allowed the separation and identification of related compounds at concentrations <0.01%. Compounds in my other articles are similar to this one(2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine)Related Products of 84746-24-7, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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Isoxazole – Wikipedia,
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Synthetic Route of C12H14N6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Author is Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju; Li, Zheng-Ming.

A series of trifluoromethyl-substituted 1,2,4-triazole Mannich base 6 and bis(1,2,4-triazole) Mannich base 7 containing pyrimidinylpiperazine rings via the Mannich reaction were synthesized and characterized by IR, 1H NMR, and elemental anal. The fungicidal tests indicated that most of compounds 6 and 7 possessed excellent fungicidal activity. Among 19 novel compounds, some showed superiority over com. fungicides Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin. Some compounds also exhibited favorable herbicidal activity in the preliminary studies. On the basis of the comparative mol. field anal. (CoMFA), five novel compounds were subsequently synthesized, their activities were estimated fairly accurately, and compounds 6-A1 and 7-A2 displayed good fungicidal activity against Pseudoperonospora cubensis (96.9 and 84.9%) as 6h and 7c, resp.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Analysis of new serotonergic anxiolytics by liquid chromatography, published in 1992-12-31, which mentions a compound: 84746-24-7, mainly applied to serotonergic anxiolytic determination liquid chromatog; HPLC serotonergic anxiolytic determination, Recommanded Product: 84746-24-7.

A simple isocratic procedure was developed for the anal. of new serotonergic anxiolytics and related compounds in bulk, pharmaceuticals, and in biol. samples. The system may be applied for the assay of other serotonergic anxiolytics of related structure such as buspirone. The HPLC assay utilized a reversed-phase C18 column, a mobile phase consisting of a mixture (55:45) of (A) buffer potassium dihydrogen phosphate (0.05M) containing sodium lauryl sulfate (0.005M) and (B) MeCN. A fluorescence detection was used with λex 237 nm; λem 374 nm. The accuracy, precision and sensitivity of the proposed method were established. Standard curves were linear with respect to concentration in the range 0.05-7.5 μg mL-1. The method also allowed the separation and identification of related compounds at concentrations <0.01%. In some applications, this compound(84746-24-7)Recommanded Product: 84746-24-7 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Isoxazole – Wikipedia,
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Application In Synthesis of 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Author is Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju; Li, Zheng-Ming.

A series of trifluoromethyl-substituted 1,2,4-triazole Mannich base 6 and bis(1,2,4-triazole) Mannich base 7 containing pyrimidinylpiperazine rings via the Mannich reaction were synthesized and characterized by IR, 1H NMR, and elemental anal. The fungicidal tests indicated that most of compounds 6 and 7 possessed excellent fungicidal activity. Among 19 novel compounds, some showed superiority over com. fungicides Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin. Some compounds also exhibited favorable herbicidal activity in the preliminary studies. On the basis of the comparative mol. field anal. (CoMFA), five novel compounds were subsequently synthesized, their activities were estimated fairly accurately, and compounds 6-A1 and 7-A2 displayed good fungicidal activity against Pseudoperonospora cubensis (96.9 and 84.9%) as 6h and 7c, resp.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Formula: C12H14N6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Author is Wang, Bao-Lei; Shi, Yan-Xia; Zhang, Shu-Jun; Ma, Yi; Wang, Hong-Xue; Zhang, Li-Yuan; Wei, Wei; Liu, Xing-Hai; Li, Yong-Hong; Li, Zheng-Ming; Li, Bao-Ju.

A series of novel carboxamide compounds containing piperazine and arylsulfonyl moieties, e.g., I, II and III have been synthesized. The bioassay results showed that some compounds exhibited favorable herbicidal activities against dicotyledonous plants and many of them possessed excellent antifungal activities. Among 24 novel compounds, some showed superiority over the com. fungicides Chlorothalonil, Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin at 500 mg/L concentration Some compounds also exhibited high KARI inhibitory activity at 100 μg/mL concentration and could be used as new KARI lead inhibitors for further studies. Moreover, SAR of these new compounds were comprehensively investigated using different computational methods in which 3D-QSAR model obtained provided useful information for further structural optimization for the discovery of new fungicides. The results of this research will contribute to explore comprehensive biol. activities of piperazine containing compounds in different areas of chem.

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Quaglia, M. G.; Farina, A.; Boxxu, E.; Dell’aquila, C. published an article about the compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine( cas:84746-24-7,SMILESS:C1(N2CCN(C3=NC=CC=N3)CC2)=NC=CC=N1 ).Product Details of 84746-24-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:84746-24-7) through the article.

A simple capillary electrophoretic method was developed for the anal. of a new generation of and their related substances: zalospirone, gepirone, ipsapirone and busipirone. All compounds run in a Tris/phosphate buffer at pH 3 as cations and the exptl. conditions allowed good resolution of four drugs and their principal impurities. The anal. were made using two different kinds of capillary. The suitability of CZE and HPLC methods for the anal. of these non-benzodiazepinic anxiolytic agents and their impurities was compared.

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Isoxazole – Wikipedia,
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HPLC of Formula: 84746-24-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, is researched, Molecular C12H14N6, CAS is 84746-24-7, about Synthesis of linked heterocycles mediated by high pressure SNAr reactions. Author is Matsumoto, Kiyoshi; Hashimoto, Shiro; Minatogawa, Hiroyuki; Munakata, Megumu; Otani, Sinichi.

A series of linked heterocycles involving piperazine and aromatic five- and six-membered heterocycles were prepared in 48-100% yields by SNAr reactions of piperazine with halo heteroaromatics under high pressure.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties, published in 2016-07-19, which mentions a compound: 84746-24-7, Name is 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, Molecular C12H14N6, Application In Synthesis of 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine.

A series of novel carboxamide compounds containing piperazine and arylsulfonyl moieties, e.g., I, II and III have been synthesized. The bioassay results showed that some compounds exhibited favorable herbicidal activities against dicotyledonous plants and many of them possessed excellent antifungal activities. Among 24 novel compounds, some showed superiority over the com. fungicides Chlorothalonil, Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin at 500 mg/L concentration Some compounds also exhibited high KARI inhibitory activity at 100 μg/mL concentration and could be used as new KARI lead inhibitors for further studies. Moreover, SAR of these new compounds were comprehensively investigated using different computational methods in which 3D-QSAR model obtained provided useful information for further structural optimization for the discovery of new fungicides. The results of this research will contribute to explore comprehensive biol. activities of piperazine containing compounds in different areas of chem.

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Reference:
Isoxazole – Wikipedia,
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