Tag: 87988-94-1

87988-94-1,87988-94-1, 5-Methylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Methyl-4-amino-isoxazole (Reiter, L. A., J. Org. Chem. 1987, 52, 2714-2726) (0.68 g, 5.1 mmol) and acetic acid (0.61 g, 10.2 mmol) were dissolved in MeOH (20 mL). Acetone (0.56 ml, 7.6 mmol) was added and the mixture was cooled to 0 – (-5) C and stirred for 1 h. Sodium cyanoborohydride (0.32 g, 5.1 mmol) was added to the reaction mixture at -5 0C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 1 h, followed by the addition of a second portion of sodium cyanoborohydride (0.1 g, 1.6 mmol). After stirring for 2 h at r.t., the mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in toluene and re- concentrated. The residue was dissolved in THF (10 mL) and trifiuoro acetic anhydride (3.2 g, 15.3 mmol) was added. The resulting mixture was stirred overnight at r.t. then for 1 h at +50 0C. The volatiles were removed in vacuo and the residue was dissolved in toluene and concentrated in vacuo to give the title compound (0.84 g , 77 %) as a solid.1H NMR (400 MHz, CDCl3) delta ppm 8.11 (s, 1 H) 4.82 – 5.03 (m, 1 H) 2.39 (s, 3 H) 1.16 (d, J=6.82 Hz, 3 H) 1.08 (d, J=6.82 Hz, 3 H); MS (CI) m/z 236 (M+).

87988-94-1 5-Methylisoxazol-4-amine 13033202, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; ASTRAZENECA AB; WO2007/40436; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87988-94-1,5-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.,87988-94-1

EXAMPLE 2 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (3-methylisoxazole-4-yl)-amide Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (150 mg) and 5-methylisoxazol-4-ylamine (60 mg). Purification by column chromatography on silica eluding with 50% ethyl acetate in heptane afforded the title compound as a white solid (110 mg). TLC Rf 0.32 (ethyl acetate). M.p. 103-104.5 C.

The synthetic route of 87988-94-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Darwin Discovery, Ltd.; US6403791; (2002); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87988-94-1,5-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.

To a solution of 4-amino-5-methylisoxazole (2.00 g, 20.39mmol; CASNo. 87988-94-1 ) in THF (50 mL) at 0 C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI, water, saturated sodium bicarbonate, and brine. The organic layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).

The synthetic route of 87988-94-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; WO2009/127948; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem