87988-94-1,87988-94-1, 5-Methylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Methyl-4-amino-isoxazole (Reiter, L. A., J. Org. Chem. 1987, 52, 2714-2726) (0.68 g, 5.1 mmol) and acetic acid (0.61 g, 10.2 mmol) were dissolved in MeOH (20 mL). Acetone (0.56 ml, 7.6 mmol) was added and the mixture was cooled to 0 – (-5) C and stirred for 1 h. Sodium cyanoborohydride (0.32 g, 5.1 mmol) was added to the reaction mixture at -5 0C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 1 h, followed by the addition of a second portion of sodium cyanoborohydride (0.1 g, 1.6 mmol). After stirring for 2 h at r.t., the mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in toluene and re- concentrated. The residue was dissolved in THF (10 mL) and trifiuoro acetic anhydride (3.2 g, 15.3 mmol) was added. The resulting mixture was stirred overnight at r.t. then for 1 h at +50 0C. The volatiles were removed in vacuo and the residue was dissolved in toluene and concentrated in vacuo to give the title compound (0.84 g , 77 %) as a solid.1H NMR (400 MHz, CDCl3) delta ppm 8.11 (s, 1 H) 4.82 – 5.03 (m, 1 H) 2.39 (s, 3 H) 1.16 (d, J=6.82 Hz, 3 H) 1.08 (d, J=6.82 Hz, 3 H); MS (CI) m/z 236 (M+).
87988-94-1 5-Methylisoxazol-4-amine 13033202, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; ASTRAZENECA AB; WO2007/40436; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem