850832-54-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.850832-54-1,Methyl 4-bromo-5-methylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
An aqueous sodium hydroxide solution (4N, 20.5 ml, 81. 8 mmol) was added to a solution of methyl 4-bromo-5-methyl- isoxazole-3-carboxylate (15.0 g, 68.2 mmol) in methanol (150 ml) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. Hydrochloric acid (6N, 13.6 ml, 81. 8 mmol) was added and the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, dried over sodium sulfate, filtered through a celite pad and concentrated under reduced pressure. The residue was triturated with diisopropyl ether to give 4- bromo-5-methylisoxazole-3-carboxylic acid (12.1 g, 86%) as a solid. MS: 160/162 [M-C02-H]-, ESI (MeOH)
The synthetic route of 850832-54-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TANABE SEIYAKU CO., LTD.; WO2005/37271; (2005); A2;,
Isoxazole – Wikipedia
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