Tag: 108655-63-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

To a solution of 3-(trifluoromethyl)isoxazol-5-amine (0.77 g) in DMF (10 mL) is added NaH (60% oil disp.). The resulting mixture is stirred for 20 min and then 4-ethoxy-1-isothiocyanato-2-nitrobenzene (see Dyson, G. M.; George, H. J.; Hunter, R. F. J. Chem. Soc. 1927, 436-445) (0.22 g) is added. The resulting mixture is stirred for 30 min, concentrated to dryness, taken-up in EtOAc, washed with brine, and purified utilizing preparatory HPLC. Yield 9%. HRMS (EI) calcd for C13H11F3N4O4S 376.0453, found 376.0450., 108655-63-6

The synthetic route of 108655-63-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.; US2003/236287; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

To a solution of 3- (trifluoromethyl) isoxazol-5-amine (1.0 g, 6.57 mmol) in CH2C12 (15 ml) is added dropwise, phenyl CHLOROFORMATE (1.8 ml, 14.45 mmol) and pyridine (1.0 ml, 13.14 mmol) at 0oC. The reaction mixture is stirred at 0oC for 30 min. The reaction mixture is washed with H20 and 1% HCI. To the combined organic layers are added pyridine (1.0 ml, 6.57 mmol), HA0 (1.0 ml), AND CH2CL2 (20 ml), and the mixture is stirred at RT for 3 hours. The reaction mixture is washed with 0. 1N HC1 and brine, dried (Na2SO4), and concentrated. The residue is recrystallized from n-hexanes to give phenyl 3- (trifluoromethyl) isoxazol-5-ylcarbamate as an off white solid 1.3 g (73%). MS (ESI-) for CLLH7F3N203 ONLY 271.0 (M-H)-.

The synthetic route of 108655-63-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/85433; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

Example 1 3-Trifluoromethyl-5-hydroxyisoxazole A solution of 36 % HCl (9.12 g, 15 eq.) and n-propanol (9.0 ml) was added to 5-amino-3-trifluoromethyl-isoxazole (0.91 g, 6.0 mmole) from Preparation 1 and heated at reflux for 23 hours. The reaction mixture was cooled, extracted with methylene chloride and distilled under reduced pressure to give 0.006 g (0.7 %) of the titled compound as a cololess liquid, b.p. 35 – 37C/1.4 mmHg.

108655-63-6 3-(Trifluoromethyl)isoxazol-5-amine 13913996, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; SHIONOGI & CO., LTD.; EP220025; (1991); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem