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Antimicrobial, antioxidant, and anticancer activities of some novel isoxazole ring containing chalcone and dihydropyrazole derivatives

Our previous work identified isoxazole-based chalcones and their dihydropyrazole derivatives as two important five-membered heterocycles having antitubercular activity. Hence, in the present study, we biologically evaluated 30 compounds, including 15 isoxazole ring-containing chalcones (17?31) and 15 dihydropyrazoles (32?46) derived from these chalcones for their antimicrobial, antioxidant, and anticancer activities. Chalcones exhibited superior antibacterial and antioxidant activities compared to dihydropyrazoles. Among the chalcones, compound 28 showed potent antibacterial (MIC = 1 mug/mL) and antioxidant activities (IC50 = 5 ± 1 mug/mL). Dihydropyrazoles, on the contrary, demonstrated remarkable antifungal and anticancer activities. Compound 46 (IC50 = 2 ± 1 mug/mL) showed excellent antifungal activity whereas two other dihydropyrazoles 45 (IC50 = 2 ± 1 mug/mL) and 39 (IC50 = 4 ± 1 mug/mL) exhibited potential anticancer activity. The compounds were also tested for their toxicity on normal human cell lines (LO2) and were found to be nontoxic. The active compounds that have emerged out of this study are potential lead molecules for the development of novel drugs against infectious diseases, oxidative stress, and cancer.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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Antitubercular evaluation of isoxazolyl chalcones

Fifteen chalcones have been synthesized by Claisen-Schmidt condensation reaction, purified and characterized by spectral and elemental analysis studies. MABA assay was employed to evaluate the antitubercular activity of the compounds. The compounds 3o and 3l exhibited comparable activity with that of the standard isoniazid. The structure activity relationships based on the results enabled to identify the essential structural feature for the activity.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem