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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 4432-31-9, Name is 2-Morpholinoethanesulfonic acid, molecular formula is C6H13NO4S. In an article, author is Pan, Hongmei,once mentioned of 4432-31-9, Recommanded Product: 4432-31-9.
Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction
A novel structure of sinomenine isoxazole derivatives is synthesised from sinomenine hydrochloride and aromatic aldehydes and requires six steps. 19 target compounds have been obtained in good yields. The sinomenine hydrochloride transforms to 4-alkynyl sinomenine, which is a key intermediate product to synthesise the target sinomenine isoxazole compounds, after a neutralisation reaction with ammonia and substitution reaction with 3-chloropropyne. Another key intermediate product is 1,3-dipole, which can be obtained from aromatic aldehyde. After treatment with hydroxylamine hydrochloride and then sodium carbonate solution, aromatic aldehyde is converted to aldehyde oxime, which reacts with N-chlorosuccinimide (NCS) to afford aryl hydroximino chloride. 1,3-Dipole is eventually formed in situ while triethylamine (TEA) in DMF is added dropwise. Then 4-alkynyl sinomenine is added to provide the sinomenine isoxazole derivative via 1,3-dipolar cycloaddition reaction as the key step. All the target compounds are characterised by melting point, H-1 NMR, C-13 NMR, HRMS and FT-IR spectroscopy.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem