With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25742-00-1,(3-Bromoisoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.
To a chilled (O0C) solution of 3-bromo-isoxazol-5-yl)-methanol (560 mg, 3.15 mmol) in CH2Cl2 (31 niL) was added Dess-Martin periodinane (2.00 g, 4.72 mmol) in 3 portions and the mixture was warmed to room temperature. After 4 hours, the mixture was diluted with Et2O (40 mL) and 1:1 mixture of aqueous solution of saturated aqueous NaHCO3 (20 mL) and saturated aqueous Na2S2O3 (20 mL) was added. After 15 hours, the aqueous layer was separated and extracted with Et2O (2 x) and EtOAc (2 x). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to afford S-bromo-isoxazole-S-carbaldehyde as a yellowish/orange solid. MS m/z 194.00 (M+ H2O); 195.97 (M+2).
25742-00-1, 25742-00-1 (3-Bromoisoxazol-5-yl)methanol 2763220, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; DISALVO, Darren; FANDRICK, Daniel Robert; HARCKEN, Christian; KUZMICH, Daniel; LEE, Thomas Wai-Ho; LIU, Pingrong; LORD, John; MAO, Can; NEU, Jochen; RAUDENBUSH, Brian Christopher; RAZAVI, Hossein; REEVES, Jonathan Timothy; SONG, Jinhua, J.; SWINAMER, Alan, David; TAN, Zhulin; WO2010/36632; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem