Tag: 62348-13-4

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Preparation of N-[4-(1-Hydroxy-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]isoxazol-5-ylcarboxamide Scheme XII, Step A: Into a 100 mL single-neck flask, 159 mg of isoxazole-5-carbonyl chloride was added dropwise to 300 mg of [2-(4-aminophenyl)-2-hydroxypropyl][(methylethyl)sulfonyl]amine (prepared in example 19) and 122 mg of triethylamine in THF (35 mL) while stirring under a nitrogen atmosphere at room temperature. The reaction was allowed to stir at this temperature for 2 h. The mixture was then poured into H2O and the desired product was extracted into ethyl acetate. The organic layer was backwashed once with H2O, dried over K2CO3, and concentrated under reduced vacuum to yield 416 mg as a solid. This material was purified via recrystallization from ethyl acetate/hexane 1:1 to yield intermediate title compound (207 mg, 51%) as a white solid. Ion spray M.S. 366.1 (M*-1). Calculated for C16 H21 N3 O5 S

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Eli Lilly and Company; US7034045; (2006); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 33 Isoxazole-5-carboxylic acid [6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-yl]-amide As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (280 mg, 1 mmol) was converted, using isoxazole-5-carbonyl chloride instead of methoxyacetyl chloride, to the title compound (290 mg, 77%) which was obtained as a white solid. MS: m/e=378.2 [M+H]+.

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

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Patent; Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew; US2009/143385; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62348-13-4

REFERENCE EXAMPLE 3 SYNTHESIS OF 6-[4-(ISOXAZOLE-5-CARBONYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC ACID (3-METHYLBUTYL)AMIDE To a stirred solution of 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide (277 mg, 1 mmol) in dichloromethane (15 mL) was added isoxazole-5-carbonyl chloride (1.0 mmol) as a dichloromethane solution in the presence of triethylamine (0.4 mL) at ambient temperature. After 1 hour the mixture was evaporated and the residue was subjected to column chromatography. Final product was isolated as a solid (0.107 g, yield 29%). 1H NMR (300 MHz, CDCl3) delta 8.34, 8.05, 7.83, 7.00, 6.86, 3.90-3.84, 3.51-3.45, 1.75-1.62, 1.53-1.46, 0.92. MS (ES+) m/z 373.3 (M+1).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Xenon Pharmaceuticals Inc.; Abreo, Melwyn; Chafev, Mikhail; Chakka, Nagasree; Chowdhury, Sultan; Fu, Jian-Min; Gschwend, Heinz, W.; Holladay, Mark, W.; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Li, Wenbao; Liu, Shifeng; Raina, Vandna; Sun, Sengen; Sun, Shaoyi; Sviridov, Serguei; Tu, Chi; Winther, Michael, D.; Zhang, Zaihui; (94 pag.)EP2316827; (2016); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound obtained in Example 1, performed in the 10ml flasks 2 Hydra possess -N, N- bis (2,2,2-trifluoro-ethyl) -4 (trifluoro Methyl) quinoline-6-amine 100mg (0.247mmol) into a 4-methyl-1,3-oxazole-5-carboxylic acid 31.4mg (0.247mmol) in dichloromethane And dissolved by stirring into a 2ml. 42ul of triethylamine (0.296mmol) and then the insert isoxazole-5-carbonyl chloride Put 24ul (0.247mmol) was stirred for 5 hours at room temperature. After the completion of the reaction by concentration under reduced pressure and column separation title compound 25mg (20%) was obtained

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; DONG-A ST CO., LTD.; CHOI, SUNG PIL; CHOI, SEUL MIN; SON, BYOUNG HWA; KIM, HYUN JUNG; KIM, JU MI; JANG, BYUNG JUN; SUNG, JI HYUN; LEE, JI HYE; KIM, EUN JIN; KANG, KYUNG KOO; KIM, SOON HOE; (56 pag.)KR2015/123006; (2015); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (S)-N- [2-OXO-3- (6-OXO-6, 7,8, 9-tetrahydro-5H- BENZOCYCLOHEPTEN-2-YL)-OXAZOLIDIN-5-YLMETHYL]-ACETAMIDE (500 mg, 1.58 mmol) in THF (15 mL) was cooled to 0 C and 1 M solution of LiHMDS in THF (3.32 mL, 3.32 mmol) was added. The mixture was stirred at 0 C for 30 minutes then ISOXAZOLE-5-CARBONYL chloride (257 mg, 1.90 mmol) was added dropwise as a solution in THF (10 ML) over 50 minutes After warming to room temperature overnight, the mixture was worked up with saturated ammonium chloride, extracted with dichloromethane, dried over sodium sulfate and concentrated in vacuo. The resulting oil was purified with column chromatography to result in the title compound. Isolated yield: 269 mg (41% Y). MS-APCI (m/z+): 412 (M+H).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/69832; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

Benzo[b]thiophene-6-ol (Compound 1) (5.86 g, 39.01 mmol) under a nitrogen atmosphereAfter 4-dimethylaminopyridine DMAP (473 mg, 3.87 mmol) was dissolved together in THF (100 mL),Additional triethylamine (4.15 g, 41.03 mmol) and isoxazole-5-acyl chloride (Compound 2) (40.99 mmol),The mixture was heated to reflux for 7 hours and then the reaction was cooled to 50 C.A mixture of water (20 mL) and acetic acid (3.67 mL) was added to give a layered solution.The organic layer is separated and the aqueous layer is discarded to obtain a solution of benzo[b]thiophene-6-isoxazole-5-carboxylate (compound 3) in THF.This solution was used directly in the next step of the synthesis.

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Wang Liping; (11 pag.)CN108558852; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 (5 mmol, 5eq) and substituted acyl chloride (1.2 mmol, 1.2 eq) were successively added to a solution of the aniline e (1.0 mmol, 1.0 eq) in 3 mL dry 1, 4 -dioxane and the mixture was stirred at room temperature overnight. 10 mL H2O and 3 mL saturated aqueous Na2CO3 was added to the mixture and it was stirred at room temperature overnight. The precipitated solid was collected by filtration and purified by silica gel column chromatography.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Zhong, Bo; Cai, Xiaohan; Chennamaneni, Snigdha; Yi, Xin; Liu, Lili; Pink, John J.; Dowlati, Afshin; Xu, Yan; Zhou, Aimin; Su, Bin; European Journal of Medicinal Chemistry; vol. 47; 1; (2012); p. 432 – 444;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

General procedure: The acid chloride (1 eq), ammonium thiocyanate (1.7 eq) and 1 drop of PEG-400 in DCM were stirred for 1 hour. 2-(4-Isopropylphenoxy)acetohydrazide (0.97 eq) was added and the reaction was stirred for 0.5 hours

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Article; Lounsbury, Nicole; Eidem, Tess; Colquhoun, Jennifer; Mateo, George; Abou-Gharbia, Magid; Dunman, Paul M.; Childers, Wayne E.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1127 – 1131;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

(e) (18 mg, 0.13 mmol) was added in a solution of 2′ (62 mg,0.10 mmol) and Et3N (25 mg, 0.25 mmol) in dry THF (1.0 mL).The mixture was stirred at room temperature for 0.5 h. The reaction completion was confirmed by TLC (DCM/MeOH/AcOH = 40:1:0.5). The solution was poured into water andextracted by ether. Collecting the organic phase was washed bybrine and dried over Na2SO4. Then it was concentrated andthe compound was Prep-HPLC to get 902136 (35 mg) as a white solid. Yield = 51%; 1H NMR (400 MHz, DMSO-d6) d: 8.352 (s, 1H),7.897-7.852 (m, 3H), 7.711-7.652 (m, 2H), 7.437-7.305 (m, 6H),7.108 (d, J = 8 Hz, 2H), 5.774 (s, 1H), 4.457-4.423 (m, 1H), 4.292-4.262 (m, 1H), 4.144-4.093 (m, 2H), 3.638-3.603 (m, 2H), 2.988-2.942 (m, 1H), 2.861-2.804 (m, 1H), 2.180-1.997 (m, 2H), 1.922-1.840 (m, 2H), 1.658-1.656 (m, 2H), 1.569-1.471 (m, 3H), 1.344(m, 1H), 1.244 (m, 2H), 1.008-0.776 (m, 5H). ESI-MS: 690.8(C40H42N4O7, [M+H]+).

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Curreli, Francesca; Haque, Kashfia; Xie, Lihua; Qiu, Qian; Xu, Jinfeng; Yong, Weizhong; Tong, Xiaohe; Debnath, Asim K.; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7618 – 7628;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

4- [2- (4-BENZO [d] isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine was diluted to 0.20 M with anhydrous DICHLOROMETHANE, then delivered to an 8 mL vial via pipette (0.20 MMOL). To the amine solution was added base (0.4 M triethylamine in DICHLOROMETHANE, 0.40 mmol). Isoxazole-5- carbonyl chloride was diluted to 0.20 M with DICHLOROMETHANE, and added at rt (0.40 MMOL). The solution was shaken overnight at rt. Polyamine scavenging resin was added (0.5 mmol). The solution was shaken overnight at rt, then filtered into an 8 mL vial. The filtrate was evaluated by MS, then concentrated using an HT-12 GeneVac. Crude was purified by HPLC (30×100 mm ODS-A C (18) 5u COLUMN). 4- [2- (4-BENZO [d] ISOTHIAZOL- 3-YL-PIPERAZIN-1-YL)-ETHYL]-PHENYLAMINE was isolated in 94.5% purity @ 254 nm, LCMS (APCI) : 434 [M+H] +.

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem