With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.
4- [2- (4-BENZO [d] isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine was diluted to 0.20 M with anhydrous DICHLOROMETHANE, then delivered to an 8 mL vial via pipette (0.20 MMOL). To the amine solution was added base (0.4 M triethylamine in DICHLOROMETHANE, 0.40 mmol). Isoxazole-5- carbonyl chloride was diluted to 0.20 M with DICHLOROMETHANE, and added at rt (0.40 MMOL). The solution was shaken overnight at rt. Polyamine scavenging resin was added (0.5 mmol). The solution was shaken overnight at rt, then filtered into an 8 mL vial. The filtrate was evaluated by MS, then concentrated using an HT-12 GeneVac. Crude was purified by HPLC (30×100 mm ODS-A C (18) 5u COLUMN). 4- [2- (4-BENZO [d] ISOTHIAZOL- 3-YL-PIPERAZIN-1-YL)-ETHYL]-PHENYLAMINE was isolated in 94.5% purity @ 254 nm, LCMS (APCI) : 434 [M+H] +.
62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem