Category: 4369-55-5

4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(2) 2,2,2-Trichloroethyl (3-phenylisoxazol-5-yl)carbamate; To a solution of 3-phenylisoxazole-5-amine (420 mg, 2.62 mmol) and pyridine (0.636 ml, 7.87 mmol) in tetrahydrofuran (5 ml) was added 2,2,2-trichloroethyl chloroformate (0.542 ml, 3.93 mmol) with ice-cooling, the mixture was stirred for 30 minutes with ice-cooling, the reaction mixture was poured into ice-water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (750 mg, 85.3percent) as a solid. 1H-NMR (CDCl3) delta; 4.88 (2H, s), 7.09 (1H, br s), 7.45 – 7.52 (3H, m), 7.77 – 7.81 (2H, m), 8.15 (1H, br s).

4369-55-5, The synthetic route of 4369-55-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4369-55-5

A mixture of (R)-2-(5-bromo-6-cyanopyridin-3-ylamino)-4-methylpentanamide (80mg, 0.257 mmol), 5-amino-3-phenylisoxazole (44 mg, 0.275 mmol), NaOPh trihydrate (55 mg,0.323 mmol), xantphos (30 mg, 0.051 mmol) and Pd2dba3 (18 mg, 0.019 mmol) in dioxane (2mL) was degassed with Ar, then was stirred at 110 ¡ãC for 20 h. HOAc (0.1 mL) was added. The mixture was concentrated in vacuo. The residue was purified by HPLC to give (R)-2-(6-cyano-5-(3-phenylisoxazol-5-ylamino)pyridin-3-ylamino)-4-methylpentanamide (15 mg).

As the paragraph descriping shows that 4369-55-5 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; SONG, Yonghong; XU, Qing; SRAN, Arvinder; BAUER, Shawn M.; JIA, Zhaozhong J.; KANE, Brian; PANDEY, Anjali; WO2013/192046; (2013); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (R)-2-(3-bromo-4-cyanophenylamino)-4-methylpentanamide (120 mg, 0.387 mmol), 5-amino-3-methylisoxazole (60 mg, 0.612 mmol), sodium phenoxide trihydrate (100 mg, 0.588 mmol), xantphos (25 mg, 0.043 mmol) and Pd2(dba)3 (20 mg, 0.021 mmol) in dioxane (3 mL) was degassed with Ar, then was heated at 170 C for 15 min by microwave. It was concentrated in vacuo. The residue was purified by HPLC to give (R)-2-(4-cyano-3-(3- methylisoxazol-5 -ylamino)phenylamino)-4-methylpentanamide (20 mg)

4369-55-5, 4369-55-5 5-Amino-3-phenylisoxazole 261201, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong, J.; SONG, Yonghong; XU, Qing; KANE, Brian; BAUER, Shawn, M.; PANDEY, Anjali; WO2012/61418; (2012); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100ml four-necked flask, 3-phenyl-5-aminoisoxazole and benzisothiazolin-3-one-2-yl acetic acid, Its molar ratio is 1:1.1, Dissolve with DMF (N,N-dimethylformamide), Adding HOBT (1-hydroxybenzotriazole) and EDCI [1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride], The molar ratio of HOBT, EDCI and 3-phenyl-5-aminoisoxazole was 1:1:1, and the reaction was completed at 25 ¡ã C for 26 h. The solution was poured into water and a large amount of solid was precipitated. Filtration, caustic washing, pickling, and washing. The crude product was obtained by column chromatography (ethyl acetate: petroleum ether = 1 : 1.1). Yield: 68.5percent. Melting point: 189 to 191 ¡ãC.

The synthetic route of 4369-55-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing Tech University; Yu Peng; Liu Biming; Pan Jian; Li Xi; Xu Yanhua; (10 pag.)CN109535153; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4369-55-5,5-Amino-3-phenylisoxazole,as a common compound, the synthetic route is as follows.

adding 1.0 equiv. (0.2 mmol) of an oxazole ring to a schlenk tube, and adding 2 mL of analytically pure ethanol,A 1% equiv. ruthenium catalyst was reacted under green light for 24-72 hours. After the reaction is completed, the solvent is removed by a rotary evaporator, and the organic phase is extracted three times with water and dichloromethane, and the organic phase is dried over anhydrous sodium sulfate, and the solvent is evaporated and then subjected to column chromatography (dichloromethane/methanol) Amine heterocyclic propylene compound.

As the paragraph descriping shows that 4369-55-5 is playing an increasingly important role.

Reference£º
Patent; Nanjing Tech University; Jiang Yaojia; Chen Yang; Luo Deping; (7 pag.)CN110041237; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem