With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4369-55-5,5-Amino-3-phenylisoxazole,as a common compound, the synthetic route is as follows.,4369-55-5
Synthesis of N-(3-Phenyl-isoxazol-5-yl)-malonamic acid ethyl ester A solution of 3-phenyl-isoxazol-5-ylamine (500 mg, 0.31 mmol) and mono-ethyl malonyl chloride (56 mg, 0.37 mmol) in dichloromethane (2 mL) was stirred at ambient temperature overnight. The mixture was diluted with water and extracted with dichloromethane. The dichloromethane layer was washed with saturated sodium bicarbonate solution, followed by brine, dried over Na2SO4, concentrated to afford 78 mg (92.85percent Yield) of N-(3-phenyl-isoxazol-5-yl)-malonamic acid ethyl ester.
4369-55-5 5-Amino-3-phenylisoxazole 261201, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; FOREST LABORATORIES HOLDINGS LIMITED; US2009/239848; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem