Category: 19788-36-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-36-4,(3,5-Dimethyl-4-isoxazolyl)methanol,as a common compound, the synthetic route is as follows.

To a solution of (3,5-dimethylisoxazol-4-yl)methanol (1.00 g, 7.86 mmol) in CH2CI2 (20 mL) at 0 C was added Dess-Martin periodinane (4.17 g, 9.83 mmol) very slowly over 10 min and the reaction mixture was warmed to rt. The reaction mixture was stirred at rt for 60 min and then filtered through Celite and washed through with CH2C12. The organic layer was dried over Na2S04, concentrated, and purified by column chromatography (15% EtOAc/hexanes) to provide the title compound (0.450 g, 46%). ? NMR (400 MHz, DMSO-d6) delta ppm 9.92 (s, 1H), 2.68 (s, 3H), 2.37 (s, 3H)., 19788-36-4

As the paragraph descriping shows that 19788-36-4 is playing an increasingly important role.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3,5-Dimethylisoxazol-4-yl)methanol (0.28 g, 1.5 mmol), methyl (2S)- 2-(1 ,3-benzoxazol-2-ylamino)-3-(4-hydroxyphenyl)propionate (0.31 g, 1 mmol) and triphenylphosphine (0.26 g, 1 mmol) were dissolved in 5 ml of tetrahydrofuran (THF). The reaction mixture was cooled to 5C. DEAD (0.52 g, 3 mmol) was then added and the reaction was stirred at room temperature for 18-24h. Subsequently, THF was evaporated to obtain the product, the title acid methyl ester. The crude product was dissolved in a THF/MeOH/H2O mixture(6:0.1 :1 , 2 ml). 1M LiOH (1.6 ml) was added and the reaction was stirred for 3 days at room temperature. Then the reaction mixture was neutralized with 1M HCl, a small amount of water was added and the mixture extracted with ethyl acetate. The solvent was evaporated. The purification was performed by chromatography. The yield was 60%. MS (ES) 407 (M+, 100%), 19788-36-4

As the paragraph descriping shows that 19788-36-4 is playing an increasingly important role.

Reference£º
Patent; ADAMED SP. Z O.O.; WO2006/67086; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19788-36-4, The titled compound was prepared by the reaction of 2-chloro-3-(4-nitrophenyl)pyrazine (Step 1 of intermediate 11) (112 mg, 0.48 mmol) with (3,5-dimethylisoxazol-4-yl)methanol (61 mg, 0.48 mmol) using cesium fluoride (216 mg, 1.43 mmol) in DMSO (8.0 mL) as per the procedure described in Step 1 of Intermediate 51 to yield 109 mg of the product; 1H NMR (300 MHz, DMSO-d6) delta 2.22 (s, 3H), 2.45 (s, 3H), 5.33 (s, 2H), 8.22 (d, = 8.7 Hz, 2H), 8.32-8.38 (m, 3H), 8.43 (s, 1H).

The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; GHARAT, Laxmikant Atmaram; HARDE, Rajendra Laxman; SHELKE, Sandeep Yadunath; PARDESHI, Shailesh Ramesh; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; (181 pag.)WO2017/21879; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(2,4-dimethylphenyl)-3-hydroxy-N-isobutylbenzenesulfonamide (76.9 mg, 0.231 mmol), (3,5- dimethylisoxazol-4-yl)methanol (36.7 mg, 0.288 mmol) and (4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9, 10, 10, 10-heptadecafluorodecyl)phenyl)diphenylphosphine (204 mg, 0.288 mmol) were added to a 2-5mL Biotage microwave vessel. Tetrahydrofuran (THF) (4 mL) was added followed by diisopropyl diazene-l,2-dicarboxylate (DIAD) (0.056 mL, 0.288 mmol). The reaction vial was sealed and left to stir overnight at RT. The reaction mixture was concentrated in vacuo and then diluted with ethyl acetate (25mL) and water (25mL). The organic fraction was separated, dried and then concentrated in vacuo to give the crude product. The crude product was dissolved in DMF: H20 (9: 1) ImL, and loaded onto a flurous column(preconditioned with ImL DMF, followed by 6mL MeOH: H20 (5: 1). The semi purified fraction was eluted with 6mL MeOH: H20 (5: 1). The fraction was concentrated down, and dissolved in 1: 1 MeOH:DMSO 1 mL and purified by mass directed autoPrep on Sunfire C18 column usingAcetonitrile Water with a Formic acid modifier. The solvent was dried under a stream of nitrogen in the Radleys blowdown apparatus to give the required product, 37.7 mg., 19788-36-4

The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BIRAULT, Veronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; WO2013/45431; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(h) 3,&-dimethvlisoxazoin-4-carbaidehyde: To a solution of (3,5dimethyhsoxazoi-4 yl)methanoi (1.00 g, 7.86 minol) in C]ET2CI2 (20 mE) at 0 C was added Dess-Martin periodinane (4.17 g, 9.83 inmol) slowly i,,fjthjn 10 nun and the resulting nrixture was warmed to it. The reaction mixture was stirred at rt for 60 mm. After completion of the reaction, the reaction mixture was filtered through Cebte and washed with Ci-12C12. The organic layer was dried overNa2SO, concentrated, and purified by silica gel colurmi chromatography (15% EtOAc/Hexanes) to provide the title compound (0.450 g, 45.73 %). ?H NMR (400 MHz, DMSO-d6) 3 ppm 9.92 (s, I H), 2.68 (s, 3 H), 2.37 (s. 3 H).

19788-36-4, The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem