19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3,5-Dimethylisoxazol-4-yl)methanol (0.28 g, 1.5 mmol), methyl (2S)- 2-(1 ,3-benzoxazol-2-ylamino)-3-(4-hydroxyphenyl)propionate (0.31 g, 1 mmol) and triphenylphosphine (0.26 g, 1 mmol) were dissolved in 5 ml of tetrahydrofuran (THF). The reaction mixture was cooled to 5C. DEAD (0.52 g, 3 mmol) was then added and the reaction was stirred at room temperature for 18-24h. Subsequently, THF was evaporated to obtain the product, the title acid methyl ester. The crude product was dissolved in a THF/MeOH/H2O mixture(6:0.1 :1 , 2 ml). 1M LiOH (1.6 ml) was added and the reaction was stirred for 3 days at room temperature. Then the reaction mixture was neutralized with 1M HCl, a small amount of water was added and the mixture extracted with ethyl acetate. The solvent was evaporated. The purification was performed by chromatography. The yield was 60%. MS (ES) 407 (M+, 100%), 19788-36-4
As the paragraph descriping shows that 19788-36-4 is playing an increasingly important role.
Reference£º
Patent; ADAMED SP. Z O.O.; WO2006/67086; (2006); A1;,
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