Tag: M.W=200-250

Wang, Liang published the artcilen-Bu₄NI-catalyzed direct amination of ethers with aryl tetrazoles and triazoles via cross-dehydrogenative coupling reaction, HPLC of Formula: 2251-79-8, the publication is Catalysis Science & Technology (2015), 5(5), 2891-2896, database is CAplus.

An efficient, metal-free protocol for direct amination of ethers with aryl tetrazoles and triazoles has been developed using tetrabutylammonium iodide (TBAI) as a catalyst and tert-Bu hydroperoxide (t-BuOOH) as an oxidant. A series of ethers, aryl tetrazoles as well as triazoles are tolerated in this system, giving the corresponding products in moderate to good yields.

Catalysis Science & Technology published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is 0, HPLC of Formula: 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Liang published the artcileTransition-Metal-Free Direct Alkylation of Aryl Tetrazoles via Intermolecular Oxidative C-N Formation, Application In Synthesis of 2251-79-8, the publication is Journal of Organic Chemistry (2014), 79(23), 11780-11786, database is CAplus and MEDLINE.

A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu₄NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C-N bond formation through sp³ C-H activation. A wide range of benzylic C-H substrates (or alkyl ethers) and aryl tetrazoles undergo this reaction smoothly to deliver the corresponding products, e.g., I, in good yields.

Journal of Organic Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Liang published the artcileRhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation, Formula: C8H5F3N4, the publication is Organic & Biomolecular Chemistry (2014), 12(40), 7923-7926, database is CAplus and MEDLINE.

Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group. This reaction provides a straightforward way for the synthesis of ortho-alkenyl aryl tetrazoles. Various functional groups tolerate the reaction conditions and afford the corresponding products in moderate to excellent yields.

Organic & Biomolecular Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is 0, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhu, Kai-qiang published the artcileIron-catalyzed oxidative dehydrogenative coupling of ethers with aryl tetrazoles, Category: isoxazole, the publication is Tetrahedron Letters (2015), 56(34), 4943-4946, database is CAplus.

An iron-catalyzed oxidative dehydrogenative coupling of ethers with aryl tetrazoles has been developed. A wide variety of tetrazoles and ethers survived the reaction conditions to deliver the corresponding hemiaminal derivatives in moderate to good yields.

Tetrahedron Letters published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C7H4BrClO2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Zhengyi published the artcilePalladium-Catalyzed Aminocarbonylation Reaction to Access 1,3,4-Oxadiazoles using Chloroform as the Carbon Monoxide Source, Computed Properties of 2251-79-8, the publication is Advanced Synthesis & Catalysis (2015), 357(16-17), 3469-3473, database is CAplus.

A palladium-catalyzed aminocarbonylation reaction of aryl halides with chloroform and tetrazoles has been developed, where chloroform was employed as the carbon monoxide (CO) source in the presence of cesium hydroxide. The in situ generated N-acylated tetrazoles were unstable and easily decomposed to afford 2,5-disubstituted 1,3,4-oxadiazoles. A wide range of tetrazoles and aryl halides reacted smoothly under the optimized reaction conditions to give the corresponding products in moderate to good yields.

Advanced Synthesis & Catalysis published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Computed Properties of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Cao, Jing published the artcileOrganocatalytic Oxidative Amidation of Aldehydes with Tetrazoles to Construct 2,5-Diaryl 1,3,4-Oxadiazoles, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Chinese Journal of Chemistry (2015), 33(11), 1239-1243, database is CAplus.

A practical and metal-free oxidative amidation of aldehydes with tetrazoles into 1,3,4-oxadiazoles was developed by employing tetrabutylammonium iodide (TBAI) as catalyst and tert-Bu hydroperoxide (TBHP) as oxidant. A wide range of 2,5-disubstituted 1,3,4-oxadiazoles was conveniently generated in moderate to good yields. Gram-scale reaction was also realized in this catalytic system.

Chinese Journal of Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Chacon Simon, Selena published the artcileDiscovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design, COA of Formula: C8H5F3N4, the publication is Journal of Medicinal Chemistry (2020), 63(8), 4315-4333, database is CAplus and MEDLINE.

The frequent deregulation of MYC and its elevated expression via multiple mechanisms drives cells to a tumorigenic state. Indeed, MYC is overexpressed in up to ~50% of human cancers and is considered a highly validated anticancer target. Recently, we discovered that WD repeat-containing protein 5 (WDR5) binds to MYC and is a critical cofactor required for the recruitment of MYC to its target genes and reported the first small mol. inhibitors of the WDR5-MYC interaction using structure-based design. These compounds display high binding affinity, but have poor physicochem. properties and are hence not suitable for in vivo studies. Herein, we conducted an NMR-based fragment screening to identify addnl. chem. matter and, using a structure-based approach, we merged a fragment hit with the previously reported sulfonamide series. Compounds in this series can disrupt the WDR5-MYC interaction in cells, and as a consequence, we observed a reduction of MYC localization to chromatin.

Journal of Medicinal Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, COA of Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Roh, Jaroslav published the artcileOne-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles, SDS of cas: 2251-79-8, the publication is Tetrahedron Letters (2010), 51(10), 1411-1414, database is CAplus.

The one-pot regioselective preparation of 5-aryl/alkyl-2-vinyl-2H-tetrazoles from 5-substituted tetrazoles via a very simple procedure using 1,2-dibromoethane and triethylamine without the need of any catalyst is described. The mechanism of this reaction is also discussed.

Tetrahedron Letters published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, SDS of cas: 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Khalili, Dariush published the artcileImpregnated copper ferrite on mesoporous graphitic carbon nitride: An efficient and reusable catalyst for promoting ligand-free click synthesis of diverse 1,2,3-triazoles and tetrazoles, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Applied Organometallic Chemistry (2019), 33(11), e5219, database is CAplus.

Synthesis of magnetic CuFe₂O₄/g-C₃N₄ hybrids via a facile method and their catalytic performances were evaluated via click chem. was reported. The structural and morphol. characterization of CuFe₂O₄, g-C₃N₄, CuFe₂O₄/g-C₃N₄ were carried out by different techniques such as X-ray diffraction, high-resolution transmission electron microscopy, field emission SEM, Fourier IR spectroscopy, vibrating sample magnetometry, thermogravimetric anal. and N₂ adsorption-desorption anal. (Brunauer-Emmett-Teller surface area). The utilization of magnetic CuFe₂O₄/g-C₃N₄ enabled superior performance in the one-pot azide-alkyne cycloaddition reaction in water using alkyl halides and epoxides as azide precursors without the need of any addnl. agents to afford triazoles I [R = cyclohexyl, allyl, Bn, etc.; Ar = Ph, 2-methoxynaphthalenyl] and II [Ar¹ = Ph, 2-methoxynaphthalenyl; R¹ = H, Ph, 4-ClC₆H₄; R² = H, Et, CH₂OPh, etc.]. Also 5-substituted 1H-tetrazoles III [Ar² = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.] were prepared via [3 + 2] cycloaddition of sodium azide and aryl nitriles by using magnetic CuFe₂O₄/g-C₃N₄ nanoparticles. In addition, the catalytic system highly fulfilled the demands of “green click chem.” with its convenient conditions, especially easy access to a variety of significant products in low catalyst loading and simple work-up and isolation procedure.

Applied Organometallic Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhu, Yizhong published the artcileOne-pot synthesis of 5-substituted 1H-tetrazoles from aryl bromides with potassium hexakis(cyano-κC)ferrate(4-) (K₄[Fe(CN)₆]) as cyanide source, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Helvetica Chimica Acta (2009), 92(1), 171-175, database is CAplus.

A one-pot procedure for the synthesis of 5-substituted 1H-tetrazoles through the three-component reaction between an aryl bromide, potassium hexakis(cyano-κC)ferrate(4-) (K₄[Fe(CN)₆]) and NaN₃ catalyzed by [Pd(OAc)₂] and ZnBr₂ in the presence of 1,4-diazabicyclo[2.2.2]octane (dabco) was developed. Furthermore, the reaction occurred under nonacidic conditions and involved a nontoxic cyanide source, making this method a quite attractive one.

Helvetica Chimica Acta published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H17Br, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem