Category: 10557-85-4

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

n-BuLi (1.6 M solution in hexanes, 6 mL, 9.6 mmol) was added to a cooled (-78C) solution of 4-iodo-3,5-dimethylisoxazole (1.47 g, 6.60 mmol) in TITF (24mL) under nitrogen. After 15 min, tributyllin chloride (26 mL, 9.60 mmol) was added and the reaction was stirred over night while warming to room temperature. The reaction was quenched by 1 M HC1, CH2C12 was added, the phases separated and the solvent were evaporated. The residue was purified by flash chromatography with heptane:CLI2Cl2 (75:25 – 0: 100) to give 3,5-dimethyl-4-(tributylstannyl)isoxazole (1.00 g, 39%).

10557-85-4, The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KARO BIO AB; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; WO2011/42475; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

) 3,5-Dimethyl-4-iodoisoxazole 64 (5.00 g, 22.4 mmol, 1.0 eq.), triethylamine (9.07 g, 89.7 mmol, 12.5 ml_, 4.0 eq.) and copper iodide (213 mg, 1.12 mmol, 0.05 eq.) were solubilized / suspended in dry dimethylformamide (50 ml_) and degassed with argon bubbling. After trimethylsilyl acetylene 44 (2.62 g, 26.9 mmol, 3.7 ml_, 1.2 eq.) dropwise addition, trans- dichlorobis(triphenylphosphine)palladium (II) (787 mg, 1.12 mmol, 0.05 eq.) was added portionwise and reaction vessel was sealed. Reaction mixture was stirred at 75C for 4h. After cooling down at room temperature, reaction mixture was diluted in 200 ml_ of diethylether and washed with a saturated solution of sodium chloride (2×100 ml_), dried over magnesium sulfate and solvents were evaporated under vacuum. The residue was purified by flash chromatography [Biotage ; column AIT 120g; eluant: Cyclohexane/ EtOAc; gradient: 100/0 -> 90/10 (12CV)] affording compound 65 (3.2 g, 74% yield) as a dark brown oil., 10557-85-4

10557-85-4 3,5-Dimethyl-4-iodoisoxazole 613883, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITE DE STRASBOURG; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON; UNIVERSITE DE FRANCHE-COMTE; MISLIN, Gaetan; SCHALK, Isabelle; PLESIAT, Patrick; PAULEN, Aurelie; (142 pag.)WO2019/243273; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.

A mixture of 4-bromophenylboronic acid (1 g, 5 mmol), 3,5-dimethyl-4-iodoisoxazole (0.93 g, 4.2 mmol), bis(triphenylphospine)palladium(II) chloride (59 mg, 2 mol %), NaHCO3 (1.06 g, 12.6 mmol) in DME (5 mL) and H2O (5 mL) was heated to 80 C. under N2 for 18 h. The reaction mixture was partitioned between 1 N HCl and EtOAc. The organic layer was washed with saturated NaHCO3, brine, dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography (5% EtOAc in hexanes) to give the title compound as a white solid (0.9 g, 86%). 1H NMR (CDCl3): delta 2.26 (s, 3H), 2.40 (s, 3H), 7.13 (d, 2H, J=8.3 Hz), 7.58 (d, 2H, J=8.3 Hz)., 10557-85-4

As the paragraph descriping shows that 10557-85-4 is playing an increasingly important role.

Reference£º
Patent; Agouron Pharmaceuticals, Inc.; US2005/176701; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Raw material 4-iodo-3,5-dimethylisoxazole25 (0.28 g, 1.3 mmol) in anhydrous THF was added dropwise to a 2.93 mol/L n-BuLi hexane solution (0.47 mL, 1.4 mmol) at -78 C under an argon atmosphere. Stirring was continued for 30 min and 8a (0.52 g, 1.3 mmol) was slowly added to the reaction mixture at -78 C and stirred for 1 h at this temperature. The reaction was quenched with 20 mL water. The mixture was warmed to room temperature and extracted with ether. The organic layer was dried over MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (v/v=6/1) as the eluent resulting in 0.23 g of 1o being obtained in 38% yield as a pale yellow solid.

10557-85-4, The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pu, Shouzhi; Li, Hui; Liu, Gang; Liu, Weijun; Cui, Shiqiang; Fan, Congbin; Tetrahedron; vol. 67; 7; (2011); p. 1438 – 1447;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-bromophenylboronic acid (1G, 5MMOL), 3, 5-dimethyl-4-iodoisoxazole (0.93g, 4.2 MMOL), bis (triphenylphospine) palladium (LI) chloride (59mg, 2MOL%), NAHC03 (1.06g, 12. 6MMOL) in DME (5mL) and H20 (5mL) was heated to 80 C under N2 for 18h. The reaction mixture was partitioned between 1 N HCI and EtOAc. The organic layer was washed with saturated NAHC03, brine, dried over NA2SO4AND concentrated. The residue was purified by silica gel chromatography (5% EtOAc in hexanes) to give the title compound as a white solid (0.9g, 86%). H NMR (CDCl3) : No. 2. 26 (s, 3H), 2.40 (s, 3H), 7.13 (d, 2H, J = 8.3 Hz), 7.58 (d, 2H, J = 8.3 Hz)., 10557-85-4

10557-85-4 3,5-Dimethyl-4-iodoisoxazole 613883, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; WO2004/74270; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.

A mixture of 4-bromophenylboronic acid (1 g, 5 mmol), 3,5-dimethyl-4-iodoisoxazole (0.93 g, 4.2 mmol), bis(triphenylphospine)palladium(II) chloride (59 mg, 2 mol %), NaHCO3 (1.06 g, 12.6 mmol) in DME (5 mL) and H2O (5 mL) was heated to 80 C. under N2 for 18 h. The reaction mixture was partitioned between 1 N HCl and EtOAc. The organic layer was washed with saturated NaHCO3, brine, dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography (5% EtOAc in hexanes) to give the title compound as a white solid (0.9 g, 86%). 1H NMR (CDCl3): delta 2.26 (s, 3H), 2.40 (s, 3H), 7.13 (d, 2H, J=8.3 Hz), 7.58 (d, 2H, J=8.3 Hz)., 10557-85-4

As the paragraph descriping shows that 10557-85-4 is playing an increasingly important role.

Reference£º
Patent; Agouron Pharmaceuticals, Inc.; US2005/176701; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Raw material 4-iodo-3,5-dimethylisoxazole25 (0.28 g, 1.3 mmol) in anhydrous THF was added dropwise to a 2.93 mol/L n-BuLi hexane solution (0.47 mL, 1.4 mmol) at -78 C under an argon atmosphere. Stirring was continued for 30 min and 8a (0.52 g, 1.3 mmol) was slowly added to the reaction mixture at -78 C and stirred for 1 h at this temperature. The reaction was quenched with 20 mL water. The mixture was warmed to room temperature and extracted with ether. The organic layer was dried over MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (v/v=6/1) as the eluent resulting in 0.23 g of 1o being obtained in 38% yield as a pale yellow solid.

10557-85-4, The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pu, Shouzhi; Li, Hui; Liu, Gang; Liu, Weijun; Cui, Shiqiang; Fan, Congbin; Tetrahedron; vol. 67; 7; (2011); p. 1438 – 1447;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon protection and liquid nitrogen acetone bath conditions,4-iodo-3,5-dimethylisoxazole (1) (1.12 g, 5 mmol) was dissolved in 50 mL of purified tetrahydrofuran.N-butyllithium (5 mmol, 2.3 mL) was added under rapid stirring,Continue to low temperature reaction for 0.5 hours;Perfluorinated cyclopentene (5 mmol, 0.7 mL) was rapidly injected with high speed stirring,Continue to low temperature reaction after 1.0 hoursThen rose to room temperature, and then add the appropriate amount of water to terminate the reaction.The solvent was removed and extracted with ether. The organic phases were combined,Washed three times with saturated brine and distilled water, and dried overnight without anhydrous MgSO4. The solvent was removed by vacuum rotary evaporation and eluted with petroleum ether as eluant. The product was purified by silica gel column and the product was 3.1 g as an orange liquid. The yield was 71%., 10557-85-4

The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangxi Science and Technology Normal University; Pu Shouzhi; Liu Gang; Ma Lele; Fan Congbin; Cui Shiqiang; (15 pag.)CN104945393; (2017); B;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.,10557-85-4

General procedure: Raw material 4-iodo-3,5-dimethylisoxazole25 (0.28 g, 1.3 mmol) in anhydrous THF was added dropwise to a 2.93 mol/L n-BuLi hexane solution (0.47 mL, 1.4 mmol) at -78 C under an argon atmosphere. Stirring was continued for 30 min and 8a (0.52 g, 1.3 mmol) was slowly added to the reaction mixture at -78 C and stirred for 1 h at this temperature. The reaction was quenched with 20 mL water. The mixture was warmed to room temperature and extracted with ether. The organic layer was dried over MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (v/v=6/1) as the eluent resulting in 0.23 g of 1o being obtained in 38% yield as a pale yellow solid.

The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pu, Shouzhi; Li, Hui; Liu, Gang; Liu, Weijun; Cui, Shiqiang; Fan, Congbin; Tetrahedron; vol. 67; 7; (2011); p. 1438 – 1447;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.

To a stirred THF solution (80 mL) of compound 6 (3.62 g, 20.10 mmol) was added dropwise a 2.5 M n-BuLi/hexane solution (8.80 mL, 22 mmol) at 195 K under nitrogen atmosphere. Stirring was continued for 30 min at 195 K, octafluorocyclopentene (C5F8) (2.80 mL, 20.50 mmol) was slowly added and the reaction mixture was stirred for 2 h at this low temperature. The reaction was quenched by water. After being extracted with ether, the organic layer was washed with 1 M aqueous HCl and water. The organic layer dried over anhydrous MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on silica gel using petroleum ether as the eluent to give 2.80 g compound 7 as pale yellow liquid in 48% yield. 1H NMR (400 MHz, CDCl3): delta 2.26 (s, 3H, -CH3), 2.43 (s, 3H, -CH3); 13C NMR (100 MHz, CDCl3): delta 10.7, 12.2, 99.9, 158.5, 170.6., 10557-85-4

10557-85-4 3,5-Dimethyl-4-iodoisoxazole 613883, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Gang; Liu, Ming; Pu, Shouzhi; Fan, Congbin; Cui, Shiqiang; Tetrahedron; vol. 68; 10; (2012); p. 2267 – 2275;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem