10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
n-BuLi (1.6 M solution in hexanes, 6 mL, 9.6 mmol) was added to a cooled (-78C) solution of 4-iodo-3,5-dimethylisoxazole (1.47 g, 6.60 mmol) in TITF (24mL) under nitrogen. After 15 min, tributyllin chloride (26 mL, 9.60 mmol) was added and the reaction was stirred over night while warming to room temperature. The reaction was quenched by 1 M HC1, CH2C12 was added, the phases separated and the solvent were evaporated. The residue was purified by flash chromatography with heptane:CLI2Cl2 (75:25 – 0: 100) to give 3,5-dimethyl-4-(tributylstannyl)isoxazole (1.00 g, 39%).
10557-85-4, The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KARO BIO AB; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; WO2011/42475; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem