Korsakov, M. K. published the artcileA new method for synthesis of atomoxetine and its interaction with azole-containing sulfonyl chlorides, Application of 5-(3-Methylisoxazol-5-yl)thiophene-2-sulfonyl chloride, the publication is Zhurnal Organichnoi ta Farmatsevtichnoi Khimii (2013), 11(4), 38-41, database is CAplus.
A new approach to the synthesis of atomoxetine using the methods of enzymic catalysis has been developed; the interaction of atomoxetine with a number of azole-containing heterocyclic sulfochlorides has been studied. The carbonyl group of 3-chloro-1-phenyl-propane-1-one was region-specifically reduced with NADPH-dependent carbonylreductase (SSCR) in phosphate buffer solution In Mitsunobu reaction with o-methylphenol the inversion of the final product configuration takes place and [R]-1-(3-chloro-1-phenypropoxy)-2-methylbenzene is formed. Its further treatment with methylamine results in the base of atomoxetine, which may be isolated from the solution as a chloride. In order to develop the novel biol. active compounds the series of sulfonyl chlorides with oxazole and isoxazole substituents were reacted with atomoxetine. The sulfonamides obtained fully comply with all criteria for the mols. – candidates for the biomedical study.
Zhurnal Organichnoi ta Farmatsevtichnoi Khimii published new progress about 1282218-14-7. 1282218-14-7 belongs to isoxazole, auxiliary class Thiophene,Isoxazole,Chloride,Sulfonyl chlorides, name is 5-(3-Methylisoxazol-5-yl)thiophene-2-sulfonyl chloride, and the molecular formula is C8H6ClNO3S2, Application of 5-(3-Methylisoxazol-5-yl)thiophene-2-sulfonyl chloride.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem