With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.
To a stirred THF solution (80 mL) of compound 6 (3.62 g, 20.10 mmol) was added dropwise a 2.5 M n-BuLi/hexane solution (8.80 mL, 22 mmol) at 195 K under nitrogen atmosphere. Stirring was continued for 30 min at 195 K, octafluorocyclopentene (C5F8) (2.80 mL, 20.50 mmol) was slowly added and the reaction mixture was stirred for 2 h at this low temperature. The reaction was quenched by water. After being extracted with ether, the organic layer was washed with 1 M aqueous HCl and water. The organic layer dried over anhydrous MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on silica gel using petroleum ether as the eluent to give 2.80 g compound 7 as pale yellow liquid in 48% yield. 1H NMR (400 MHz, CDCl3): delta 2.26 (s, 3H, -CH3), 2.43 (s, 3H, -CH3); 13C NMR (100 MHz, CDCl3): delta 10.7, 12.2, 99.9, 158.5, 170.6., 10557-85-4
10557-85-4 3,5-Dimethyl-4-iodoisoxazole 613883, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Liu, Gang; Liu, Ming; Pu, Shouzhi; Fan, Congbin; Cui, Shiqiang; Tetrahedron; vol. 68; 10; (2012); p. 2267 – 2275;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem