10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
) 3,5-Dimethyl-4-iodoisoxazole 64 (5.00 g, 22.4 mmol, 1.0 eq.), triethylamine (9.07 g, 89.7 mmol, 12.5 ml_, 4.0 eq.) and copper iodide (213 mg, 1.12 mmol, 0.05 eq.) were solubilized / suspended in dry dimethylformamide (50 ml_) and degassed with argon bubbling. After trimethylsilyl acetylene 44 (2.62 g, 26.9 mmol, 3.7 ml_, 1.2 eq.) dropwise addition, trans- dichlorobis(triphenylphosphine)palladium (II) (787 mg, 1.12 mmol, 0.05 eq.) was added portionwise and reaction vessel was sealed. Reaction mixture was stirred at 75C for 4h. After cooling down at room temperature, reaction mixture was diluted in 200 ml_ of diethylether and washed with a saturated solution of sodium chloride (2×100 ml_), dried over magnesium sulfate and solvents were evaporated under vacuum. The residue was purified by flash chromatography [Biotage ; column AIT 120g; eluant: Cyclohexane/ EtOAc; gradient: 100/0 -> 90/10 (12CV)] affording compound 65 (3.2 g, 74% yield) as a dark brown oil., 10557-85-4
10557-85-4 3,5-Dimethyl-4-iodoisoxazole 613883, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; UNIVERSITE DE STRASBOURG; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON; UNIVERSITE DE FRANCHE-COMTE; MISLIN, Gaetan; SCHALK, Isabelle; PLESIAT, Patrick; PAULEN, Aurelie; (142 pag.)WO2019/243273; (2019); A1;,
Isoxazole – Wikipedia
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