With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228689-61-9,Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.
[00501] Step 4: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid: Lithium hydroxide (2g, 47.7mmol) was added to a solution of 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (7g, 23.6mmol) in MeOH (50mL) and H20 (lOmL), and the reaction was stirred at 60C for 1 hour. Acidic work-up the title compound., 1228689-61-9
The synthetic route of 1228689-61-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.; WO2012/78805; (2012); A1;,
Isoxazole – Wikipedia
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