With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.
(e) (18 mg, 0.13 mmol) was added in a solution of 2′ (62 mg,0.10 mmol) and Et3N (25 mg, 0.25 mmol) in dry THF (1.0 mL).The mixture was stirred at room temperature for 0.5 h. The reaction completion was confirmed by TLC (DCM/MeOH/AcOH = 40:1:0.5). The solution was poured into water andextracted by ether. Collecting the organic phase was washed bybrine and dried over Na2SO4. Then it was concentrated andthe compound was Prep-HPLC to get 902136 (35 mg) as a white solid. Yield = 51%; 1H NMR (400 MHz, DMSO-d6) d: 8.352 (s, 1H),7.897-7.852 (m, 3H), 7.711-7.652 (m, 2H), 7.437-7.305 (m, 6H),7.108 (d, J = 8 Hz, 2H), 5.774 (s, 1H), 4.457-4.423 (m, 1H), 4.292-4.262 (m, 1H), 4.144-4.093 (m, 2H), 3.638-3.603 (m, 2H), 2.988-2.942 (m, 1H), 2.861-2.804 (m, 1H), 2.180-1.997 (m, 2H), 1.922-1.840 (m, 2H), 1.658-1.656 (m, 2H), 1.569-1.471 (m, 3H), 1.344(m, 1H), 1.244 (m, 2H), 1.008-0.776 (m, 5H). ESI-MS: 690.8(C40H42N4O7, [M+H]+).
The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Curreli, Francesca; Haque, Kashfia; Xie, Lihua; Qiu, Qian; Xu, Jinfeng; Yong, Weizhong; Tong, Xiaohe; Debnath, Asim K.; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7618 – 7628;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem