62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of (S)-N- [2-OXO-3- (6-OXO-6, 7,8, 9-tetrahydro-5H- BENZOCYCLOHEPTEN-2-YL)-OXAZOLIDIN-5-YLMETHYL]-ACETAMIDE (500 mg, 1.58 mmol) in THF (15 mL) was cooled to 0 C and 1 M solution of LiHMDS in THF (3.32 mL, 3.32 mmol) was added. The mixture was stirred at 0 C for 30 minutes then ISOXAZOLE-5-CARBONYL chloride (257 mg, 1.90 mmol) was added dropwise as a solution in THF (10 ML) over 50 minutes After warming to room temperature overnight, the mixture was worked up with saturated ammonium chloride, extracted with dichloromethane, dried over sodium sulfate and concentrated in vacuo. The resulting oil was purified with column chromatography to result in the title compound. Isolated yield: 269 mg (41% Y). MS-APCI (m/z+): 412 (M+H).
62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/69832; (2004); A2;,
Isoxazole – Wikipedia
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