Qi, Suo-Suo published the artcileRegioselective catalytic asymmetric N-alkylation of isoxazol-5-ones with para-quinone methides, Application In Synthesis of 1076-59-1, the publication is Organic & Biomolecular Chemistry (2020), 18(13), 2398-2404, database is CAplus and MEDLINE.
A highly regioselective and enantioselective N-alkylation of isoxazol-5-ones with para-quinone methides promoted by bi-functional squaramide catalysts was developed. This unexpected asym. N-addition of isoxazolinones afforded a series of enantioenriched N-diarylmethane substituted isoxazolinones I (R1 = H, 2-Me, 4-CF3, etc.; R2 = H, Me, Et, Ph, Bn; R3 = Ph, 2-MeOC6H4, 2-naphthyl, etc.) with high yields and enantioselectivities (up to 97 : 3 er). This reaction not only provides a useful approach for intermol. chiral C-N bond formation but also demonstrates the immense potential of isoxazol-5-ones as N-nucleophiles in catalytic asym. reactions.
Organic & Biomolecular Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Application In Synthesis of 1076-59-1.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem