With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-05-8,Isoxazol-5-amine,as a common compound, the synthetic route is as follows.
Example 37 Synthesis of ethyl 2-(2,4,5-trifluorobenzoyl)-3-(isoxazol-5-ylamino)acrylate (Compound No. 87) Ethyl 2,4,5-trifluorobenzoylacetate (1.50 g), 1.36 g of ethyl orthoformate and 2.80 g of acetic anhydride were combined, followed by heating at 130C for 3 hours. Excess ethyl orthoformate and acetic anhydride were distilled off. The residue was dissolved in 30 ml of chloroform. To the resulting solution, a solution of 512 mg of 5-aminoisoxazole in 30 ml of methanol was added, followed by stirring at room temperature for 3 hours. The solvent was distilled off. The residue was purified using a silica gel column (hexane:chloroform = 1:1), whereby 1.74 g of the title compound was obtained as a colorless solid.
14678-05-8 Isoxazol-5-amine 84591, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; WAKUNAGA SEIYAKU KABUSHIKI KAISHA; FUJISAWA PHARMACEUTICAL CO., LTD.; EP700912; (1996); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem