With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10557-85-4,3,5-Dimethyl-4-iodoisoxazole,as a common compound, the synthetic route is as follows.
To a solution of 4-iodo-3,5-dimethylisoxazole (2 g, 8.97 mmol, Eq: 1.00) and ethynyltrimethylsilane (1.06 g, 1.51 ml, 10.8 mmol, Eq: 1.2) in triethylamine (3.63 g, 5.00 ml, 35.9 mmol, Eq: 4) and DMF (17.9 ml) was added bis(triphenylphosphine)palladium (II) chloride (315 mg, 448 mumol, Eq: 0.05) and copper (I) iodide (40.2 mg, 448 mumol, Eq: 0.05). The mixture was heated to 75 C. for 2 hrs, diluted ether, washed with brine (2*), and dried over MgSO4. Concentration of the organic layer onto silica gel and purification by flash chromatography (5-18% ethyl acetate/hexane gradient) gave 3,5-dimethyl-4-((trimethylsilyl)ethynyl)isoxazole (1.07 g, 5.53 mmol, 61.7% yield) as a brown oil.
As the paragraph descriping shows that 10557-85-4 is playing an increasingly important role.
Reference£º
Patent; Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Bhagirath, Niala; Kennedy-Smith, Joshua; Wilhelm, Robert Stephen; US2013/158049; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem