With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of (R)-methyl l-((l-(tert-butoxycarbonyl)pyrrolidin-2-yl)methyl)-2-imino- 2,3-dihydro-lH-benzo[d]imidazole-5-carboxylate (1 120 mg, 2.99 mmol) (Intermediate 13, Step 3), isoxazole-5-carboxylic acid (507.3 mg, 4.49 mmol), and DIPEA (1.03 mL, 5.9 8mmol) in DMF (6 mL)) was added HATU (1705 mg, 4.49 mmol). The resultant mixture was stirred at rt for 2 hours. The reaction mixture was evaporated, then the crude mixture was diluted with DCM and washed with brine. The organic layers were separated and dried with MgS04, filtered and concentrated to crude oil. This crude oil was purified by chromatography to obtain 1380 mg of (R)-methyl l-((l-(tert-butoxycarbonyl)pyrrolidin-2-yl)methyl)-2-(isoxazole-5-carboxamido)-lH- benzo[d]imidazole-5-carboxylate.
21169-71-1 Isoxazole-5-carboxylic acid 2060599, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth, A.; OWENS, Tim, A.; WO2014/36016; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem