206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of (3-(4-bromophenyl)isoxazol-5-yl)methanol (AA; 0.5 g, 1.96 mmol) in CH2CI2 (15 mL) under inert atmosphere were added pyridine (0.39 mL, 4.91 mmol) and p- dimethylaminopyridine (0.024 mg, 0.19 mmol) at 0 C. After the addition of 4-nitrophenyl carbonochloridate (DK; 0.39 g, 1.93 mmol) at 0 C, the reaction mixture was warmed to RT and stirred for 12 h. The reaction was monitored by TLC. After complete consumption of the starting material, the reaction mixture was diluted with a saturated ammonium chloride solution (20 mL) and the compound was extracted with CH2CI2 (3×20 mL). The combined organic extracts were washed with water (20 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The crude was triturated with pentane (2×15 mL) to afford crude DL (710 mg) as an off-white solid. FontWeight=”Bold” FontSize=”10″ H NMR (500 MHz, CDCI3): delta 8.30 (d, / = 9.5 Hz, 2H), 8.17 (d, J = 6.8 Hz, 1H), 7.70-7.59 (m, 5H), 7.40 (d, J = 9.5 Hz, 2H), 6.91 (d, / = 9.0 Hz, 1H), 6.73 (s, 1H), 5.43 (s, 2H), 5.34 (s, 1H).
206055-91-6, 206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William, J.; YATES, Christopher, M.; RAFFERTY, Stephen, W.; WO2014/117090; (2014); A1;,
Isoxazole – Wikipedia
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