131052-47-6, (3,5-Dimethylisoxazol-4-yl)methanamine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,131052-47-6
To a solution of [4-(3 ,4-dihydro- 1 H-isoquinoline-2-sulfonyl)-phenyl] -carbamic acid phenyl ester (370 mg, 0.9 mmoL), C-(3,5-dimethyl-isoxazol-4-yl)-methylamine (115 mg, 0.9 mmoL) and Et3N (0.3 mL, 2.1 mmoL) in MeCN (12 mL) at room temperature and stirred for lh at 80C. The reaction mixture was concentrated to dryness in vacuum and part of the residue (260 mg) was purified by Prep-HPLC to give 1- [4-(3 ,4-dihydro- 1 H-isoquinoline-2-sulfonyl)-phenyl] -3 -(3,5- dimethyl-isoxazol-4-ylmethyl)-urea (41 mg, yield: 10%) as a white solid. ?H NIVIR (300 IVIHz, DMSO-d6): oe = 8.95 (s, 1H), 7.68 (d, J= 8.7 Hz, 2H), 7.59 (d, J= 9.0 Hz, 2H), 7.15-7.11 (m, 4H), 6.67(t,J= 5.7Hz, 1H), 4.13 (s, 2H), 4.05 (d,J= 5.1 Hz, 2H), 3.23 (t,J 5.7 Hz, 2H), 2.84 (t,J4.8 Hz, 2H), 2.37 (s, 3H), 2.20 (s, 3H). MS: m/z 441.0 (M+H).
131052-47-6 (3,5-Dimethylisoxazol-4-yl)methanamine 11018874, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Isoxazole – Wikipedia
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