Li, Hai-ying published the artcileEffect of ulinastatin and parecoxib sodium on intrapulmonary shunt fraction during one lung ventilation, SDS of cas: 198470-85-8, the publication is Shiyong Yaowu Yu Linchuang (2017), 20(1), 30-34, database is CAplus.
Objective: To explore the effect of ulinastatin and parecoxib sodium on intrapulmonary shunt during one lung ventilation. Methods: One hundred patients receiving one lung ventilation treatment for esophageal cancer from Apr. 2014 to Apr. 2015 were involved as the observation objects. According to the patient preference, patients were divided into group A (n=50) and group B (n=50). The same induction of anesthesia and anesthesia drugs were given to them to maintain the same depth of anesthesia. Half an hour before anesthesia, 40 mg parecoxib sodium was given to group A, and 50 U UTI was given to group B. The mean airway pressure, heart rate, mean arterial pressure, oxygen saturation, arterial carbon dioxide partial pressure, pulmonary shunt fraction, interleukin (IL)-6, IL-8 Junior necrosis factor α and C-protein expression were compared at the following time points: after induction of anesthesia (S1 period), 0.5 h after one-Lung ventilation (S2 period), 1 h after one lung ventilation (S3 period) and 0.5 h after restoring lung ventilation (S4 period). Results: The mean arterial pressure of group A (77.9±11.5) was higher than that of group B (73.6±9.1) at the period of S4, the difference was statistically significant (P<0.05). The arterial carbon dioxide tension of group A (41.4±3.8, 41.8±3.4, 41.7±2.8) was higher than that of group B (42.7±2.1, 42.7±2.1, 44.8±3.7) at the period of S2, S3 and S4, the difference were statistically significant (P<0.05). The pulmonary shunt fraction of group A was lower than that of group B on the period of S2 and S3. The pulmonary shunt fractions of the two groups on the period of S2 and S3 were higher than those on the period of S4. Conclusion: Parecoxib sodium and ulinastatin have protective effect on one lung ventilation, but parecoxib sodium reduces intrapulmonary shunt fraction more significantly which can avoid the damage to the lung tissue to some extent.
Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, SDS of cas: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem