Chen, Wei published the artcileEffects of parecoxib sodium preemptive analgesia on postoperative inflammatory cytokines and stress responses in elderly patients undergoing total hip replacement, COA of Formula: C19H17N2NaO4S, the publication is Huaxi Yixue (2015), 30(6), 1067-1070, database is CAplus.
Objective: To investigate whether parecoxib sodium preemptive analgesia reduces inflammatory cytokines and stress hormones production in elderly patients after total hip replacement. Methods: Sixty patients with American Society of Anesthesiologists Classification I-II undergoing total hip replacement for femoral neck fracture or aseptic necrosis of the femoral head, aged between 60 and 90 years with a body weight more than 50 kg, were randomly divided into preemptive analgesia group (group P, n = 30) and control group (group C, n = 30). The patients in group P received parecoxib sodium 40 mg i.v. 30 min before skin incision, and another 20 mg 8 h after the first administration. All the patients in the two groups received the administration of patient-controlled analgesia sufentanyl. We recorded blood levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), cortisol (COR), adrenaline (AD) and noradrenaline (NAD) 30 min before skin incision, and 1 h, 6 h, 12 h and 24 h postoperatively. Results: The blood levels of IL-6, TNF-α, COR, AD and NAD in group P at 1 h, 6 h, 12 h or 24 h postoperatively were significantly lower than those in group C (P<0.05). Conclusion: Parecoxib sodium preemptive analgesia reduces postoperative inflammatory cytokines and stress hormones production in elderly patients undergoing total hip replacement.
Huaxi Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem