Wang, Afang’s team published research in Yaowu Liuxingbingxue Zazhi in 25 | CAS: 198470-85-8

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H11BO2, Formula: C19H17N2NaO4S.

Wang, Afang published the artcileRetrospective analysis on the inhibiting effect of parecoxib sodium on the inflammatory factors and stress response in patients after hip and knee replacement surgery, Formula: C19H17N2NaO4S, the publication is Yaowu Liuxingbingxue Zazhi (2016), 25(3), 146-149, database is CAplus.

Objective: To evaluate the stress reaction and inflammatory factor inhibition effect of parecoxib sodium continuous pumped after hip and knee arthroplasty, and provide a reference for the orthopaedic perioperative analgesic solution Methods: 52 cases of total hip, semi hip and knee joint surface replacement patientsâ€?clin. data were retrospectively analyzed, which divided into observation group and control group according to analgesic method, 26 cases in each group. The control group received bupivacaine for patient controlled epidural analgesia therapy after operation, patients in the observation group combined with parecoxib sodium i.v. injection pumped, 5 mg per h. The level of pain relief in different time points were observed The levels of plasma inflammatory factor, cortisol (Cor), and adrenocorticotropic hormone (Glu) were compared in the two groups. Results: The VAS score of observation group was lower than that of the control group in every time points (P<0.05). The 0 and I pain levels of IL-6 and IL-1β in the observation group were significantly higher than those in the control group (P>0.05). The levels of IL-6 and IL-1β were significantly different between two groups (Glu), and the levels of Cor and Glu were significantly lower in two groups (P<0.05). The index level of observation group were significantly lower than the control group (P<0.05). Conclusion: Parecoxib sodium continuous pumped could alleviate the pain of hip and knee replacement in patients with postoperative, reduce the levels of inflammatory factors and stress level, it was worth clin. promotion.

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H11BO2, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem