With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.
5765-44-6, N-bromosuccinimide (21.4 g, 120 mmole), 5-methylisoxazole (9.97g, 120 mmole) and benzoylperoxide (2.41 g, 12.0 mmole) in carbon tetrachloride (250 mL) were heated while stirring at [80C] for 6 h. The reaction mixture was filtered and then concentrated by rotary evaporation. Distillation at reduced pressure (bp [54-57 C,] 0.5 mm Hg) provided pure product as a colorless oil (14.00 g, 72% yield).
The synthetic route of 5765-44-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TARGACEPT, INC.; WO2004/9599; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem