With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.618383-47-4,3-(4-Methoxyphenyl)isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
618383-47-4, Trimethylsilyldiazomethane (3.50 mL of a 2 M soln in Et20, 7.01 mmol) was added to a stirred solution of 3-(4-methoxyphenyl)-5-isoxazolecarboxyIic acid (0.96 g, 4.38 mmol) in dry MeOH (4.38 mL) and dry CH2C12 (39 mL) at 25 C under N2. The reaction was stirred at 25 C for 2 h. The reaction mixture was concentrated in vacuo to afford methyl 3-(4-methoxyphenyl)isoxazole- 5-carboxyIate, as a colorless solid. LCMS calc = 234 08; found = 233.98 (M+H)+. 1H NMR (600 MHz, CDC13): delta 7.76 (d, J= 8.4 Hz, 2 H); 7.19 (s, 1 H); 6.98 (d, J- 8.4 Hz, 2 H); 3.99 (s, 3 H); 3.86 (s, 3 H).
The synthetic route of 618383-47-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LU, Zhijian; CHEN, Yi-Heng; SMITH, Cameron; LI, Hong; THOMPSON, Christopher, F.; SWEIS, Ramzi; SINCLAIR, Peter; KALLASHI, Florida; HUNT, Julianne; ADAMSON, Samantha, E.; DONG, Guizhen; ONDEYKA, Debra, L.; QIAN, Xiaoxia; SUN, Wanying; VACHAL, Petr; ZHAO, Kake; WO2012/58187; (2012); A1;,
Isoxazole – Wikipedia
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