Tag: 5765-44-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.

5765-44-6, N-bromosuccinimide (21.4 g, 120 mmole), 5-methylisoxazole (9.97g, 120 mmole) and benzoylperoxide (2.41 g, 12.0 mmole) in carbon tetrachloride (250 mL) were heated while stirring at [80C] for 6 h. The reaction mixture was filtered and then concentrated by rotary evaporation. Distillation at reduced pressure (bp [54-57 C,] 0.5 mm Hg) provided pure product as a colorless oil (14.00 g, 72% yield).

The synthetic route of 5765-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TARGACEPT, INC.; WO2004/9599; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

5765-44-6, 5-Methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 Ethyl 2-amino-5-cyano-6-methyl-4-(3-phenyl-1,7-naphthyridin-5-yl)-1,4-dihydropyridine-3-carboxylate STR24 2 g (8.5 mmol) of 3-phenyl-1,7-naphthyridine-5-carboxaldehyde are suspended in 20 ml of ethanol and stirred with 0.7 ml (8.5 mmol) of 5-methylisoxazole. A solution of 196 mg of sodium in 14 ml of ethanol is added and the mixture is stirred for 2 hours at 50 C. 1.42 g of ethyl amidinoacetate hydrochloride and 0.51 ml (8.5 mmol) of acetic acid are added and the mixture is boiled for 16 hours. After cooling, 10 g of silica gel are added and the mixture is concentrated in vacuo. The residue is chromatographed on a silica gel column using toluene/ethyl acetate mixtures. After concentration of the pure fractions, the product is crystallized by trituration with ether. 2 g of crystals are obtained.

As the paragraph descriping shows that 5765-44-6 is playing an increasingly important role.

Reference£º
Patent; Bayer Aktiengesellschaft; US5434153; (1995); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem