Yuan, Fen published the artcilePrevention and treatment of dezocine combined parecoxib sodium on of patients with postoperative hyperalgesia after remifentanil anesthesia, Formula: C19H17N2NaO4S, the publication is Xinjiang Yike Daxue Xuebao (2016), 39(7), 869-872, database is CAplus.
Objective To explore the prevention and treatment of dezocine combined parecoxib sodium on patients with postoperative hyperalgesia after remifentanil anesthesia. Methods 489 cases of patients treated with operation in our hospital from March 2014 to Dec. 2015 were divided into exptl. group (245 cases) and control group (244 cases) randomly. The exptl. group was administered parecoxib sodium before operation and intraoperative dezocine, and the control group were treated with single parecoxib sodium before operation. The time of extubation, recovery of spontaneous breathing and recovery of consciousness of the two groups after operation were observed The dynamic heart rates (HR), mean arterial pressure (MAP) and pain were recorded and/or evaluated before and after operation in two groups. Results The time of extubation, recovery of spontaneous breathing and recovery of consciousness of the exptl. group were significantly shorter than those of the control group, while the HR and MAP after operation of the exptl. group were significantly better than those of the control group; the pain scores of the exptl. group after operation were significantly better than those of the control group (P<0.01). The rate of adverse reactions of the exptl. group was 13.06%, while that of the control group was 12.70%, which was no significant difference between them (P>0.05). Conclusion The prevention and treatment of dezocine combined parecoxib sodium on patients with postoperative hyperalgesia after remifentanil anesthesia were remarkable with stable postoperative hemodynamics, which was worthy of application in clin.
Xinjiang Yike Daxue Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C30H24BrCuN2P, Formula: C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem