Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3235-67-4, is researched, Molecular C7H13NO2, about Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs, the main research direction is water solubility propofol prodrug pharmacodynamics solubility.Category: isoxazole.
In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clin.) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clin. benefits of propofol. The exptl. results showed the potential of such compounds as water-soluble prodrugs of propofol.
When you point to this article, it is believed that you are also very interested in this compound(3235-67-4)Category: isoxazole and due to space limitations, I can only present the most important information.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem