The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine( cas:84746-24-7 ) is researched.SDS of cas: 84746-24-7.Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju; Li, Zheng-Ming published the article 《Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings》 about this compound( cas:84746-24-7 ) in Journal of Agricultural and Food Chemistry. Keywords: trifluoromethyl triazole preparation fungicide Pseudoperonospora CoMFA. Let’s learn more about this compound (cas:84746-24-7).
A series of trifluoromethyl-substituted 1,2,4-triazole Mannich base 6 and bis(1,2,4-triazole) Mannich base 7 containing pyrimidinylpiperazine rings via the Mannich reaction were synthesized and characterized by IR, 1H NMR, and elemental anal. The fungicidal tests indicated that most of compounds 6 and 7 possessed excellent fungicidal activity. Among 19 novel compounds, some showed superiority over com. fungicides Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin. Some compounds also exhibited favorable herbicidal activity in the preliminary studies. On the basis of the comparative mol. field anal. (CoMFA), five novel compounds were subsequently synthesized, their activities were estimated fairly accurately, and compounds 6-A1 and 7-A2 displayed good fungicidal activity against Pseudoperonospora cubensis (96.9 and 84.9%) as 6h and 7c, resp.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem