With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7063-99-2,Ethyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.,7063-99-2
Hydrazine hydrate (1 g, 20 mmol) was added to a solution of 1b (1.00g, 21 mmol) in EtOH (40 mL) at ambient temperature. The reaction was refluxed for 6 h and concentrated under reduced pressure. The reaction mixture was extracted with EtOAc followed by extraction with brine. The organic phase was dried over Na2SO4 overnight and the solvent was removed in vacuo. The crude product was purified by silica gel column chromatography to yield the target product 1d (yield: 73%). 1HNMR (300 MHz, DMSO-d6 ) delta 12.66 (s, 1H), 8.12 (dd, J = 7.5, 1.9 Hz, 2H), 7.81-7.65 (m, 3H), 7.62 (s, 1H), 4.41 (q, J = 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H).
7063-99-2 Ethyl 5-phenylisoxazole-3-carboxylate 571142, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Article; Hao, Qingjing; He, Mengting; Jiang, Kaixuan; Shang, Yanguo; Wang, Jinxin; Bioorganic and medicinal chemistry letters; vol. 30; 10; (2020);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem