1136-45-4, 5-Methyl-3-phenylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1.08 g of 93% diethyl cyanophosphonate and 0.92 ml of triethylamine were added to a mixture of 1.22 g of 3-phenyl-5-methylisoxazole-4-carboxylic acid, 1.87 g of Compound 1B as its base and 30 ml of anhydrous dimethylformamide stirred at 0-5C. The temperature was allowed to rise to 20-25C and, after 3.5 hours’ stirring, the mixture was poured into 300 ml of water and extracted with ethyl acetate. The combined organic layers were washed with 5% aqueous sodium carbonate and water. After drying on sodium sulphate, the solvent was removed in vacuo. The crude was crystallised from ethanol to yield 2.11 g (75%) of the title compound, melting at 139-142C.1H-NMR (200MHz, CDCl3, delta): 7.60-7.70, m, 2H, phenyl H2, H6; 7.45-7.55, m, 3H, phenyl H3, H4, H5; 6.95, dd, 1H, methoxyphenyl H4; 6.85, d, 1H, methoxyphenyl H6; 6.75, d, 1H, methoxyphenyl H3; 6.25, t, 1H, NH; 3.82, s, 3H, OCH3; 3.40, q, 2H, NHCH2; 2.80-2.95, m, 4H, 2 piperazine CH2s; 2.69, s, 3H, CH3; 2.40-2.55, m, 4H, 2 piperazine CH2s; 2.30, t, 2H, CONHCH2CH2CH2N; 1.55-1.70, m, 2H, CH2CH2CH2.
1136-45-4, 1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; Leonardi, Amedeo; EP1226131; (2003); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem