With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57351-99-2,5-Methylisoxazole-3-carbonitrile,as a common compound, the synthetic route is as follows.,57351-99-2
Step 1 : To a solution of compound 197 (800 mg, 7.40 mmol) in DCE (30 ml.) was added NBS (2.79 g, 15.5 mmol) and AIBN (60.8 mg, 0.375 mmol). The reaction stirred at 85 C for overnight. Concentrate to give the cream solid. Water (20 ml.) was added, and extracted with EtOAc (30 mL x 2). The combined organic layers were washed with brine (20 ml_), dried over Na2S04 and concentrated to give compound 198(1 .44 g, 2.90 mmol) as an off-white semi-solid, which was taken into the next step without further purification.
57351-99-2 5-Methylisoxazole-3-carbonitrile 24229456, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William; WO2013/132376; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem