87988-94-1, 5-Methylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
87988-94-1, To a stirred slurry of 4-methyl-3-[6-(4-methylpiperazm-l-yl)-4-oxoquinazolin-3(4H)-yl]benzoic acid (0.38 g) in DMF (50 ml) was added 4-amino-5-methylisoxazole hydrochloride (0.27 g), EtaATU (0.68 g) and triethylamine (0.55 ml) and the reaction mixture stirred at room temperature for 16 hours. The reaction mixture was diluted with water and extarcted with ethyl acetate. The ethyl aceate layer was washed with IN NaOH and dried (magnesium sulphate). The residue was purified by column chromatography on a silica column using initially ethyl acetate and then a 4: 1 mixture of ethyl acetate and methanol as eluent. There was thus obtained the title compound (150 mg); NMR Spectrum: (DMSOd6) 2.15 (s, 3Eta), 2.40 (s, 3H), 2.83 (m, 4H), 3.15 (s, 3H), 3.40 (m, 4H), 7.50 (d, IH), 7.60 (d, IH), 7.64 (m, 2H), 7.98 (s, IH), 8.04 (d, IH), 8.13 (s, IH), 8.70 (s, IH), 10.10 (s, IH); Mass Spectrum: M+H+ 459.The 4-amino-5-methylisoxazole hydrochloride used as starting material was prepared using the procedures detailed in J. Org. Chem 1987, 2714-2716.
As the paragraph descriping shows that 87988-94-1 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/90143; (2006); A1;,
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