With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42831-50-5,5-Methylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
A round bottomed flask equipped with a mechanical stiner, condenser, thermometer pocket and a stopper were added 5-Methylisoxazole-4-carboxylic acid (3.00 g, 0.02 mol) and Thionyl chloride (14.66 g, 0.12 mol) and the reaction mixture was gradually heated to 45¡À5C and stined at same temperature for 2 to 3 h. The progress of the reaction was monitored by TLC (Acid chloride was analyzed as corresponding methyl ester by quenching the samplein methanol). After the completion of reaction, the reaction mixture was concentrated under reduced pressure at 45¡À5C to afford 5-Methylisoxazole-4-carbonyl chloride as a liquid (0.59 mol).
42831-50-5, 42831-50-5 5-Methylisoxazole-4-carboxylic acid 1425240, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; BIOCON LIMITED; PALLE, Venkata, Raghavendracharyulu; BHAT, Ramakrishna, Parameshwar; KALIAPPAN, Mariappan; BABU, Jithendra, R.; SHANMUGHASAMY, Rajmahendra; (39 pag.)WO2016/203410; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem