With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3405-77-4,5-Methylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 2a (3.0g, 6.7mmol) in anhydrous DCM (30mL) was added CF3COOH (5.0mL, 67mmol) slowly at 0¡ãC. Then, the reaction mixture was stirred at RT for 2h and then concentrated. To a solution of the residue obtained in DCM (40mL) was added Et3N drop-wise to adjust the pH to 7.0at 0¡ãC, and then butyric acid (0.60g, 6.7mmol), EDCI (1.53g, 8.0mmol) and HOBt (1.08g, 8.0mmol) were sequentially added. After 20min, Et3N (3.8mL, 26.8mmol) was added drop-wise. Then, the reaction mixture was stirred at RT for 3h, followed by washing with H2O (50mL¡Á2), saturated citric acid solution (50mL¡Á2), saturated NaHCO3 solution (50mL¡Á2) and brine (50mL¡Á2). The organic phase was dried over Na2SO4 and concentrated, and the residue was purified by column chromatography (EtOAc: petroleum ether, 4: 1 v/v) to afford the pure product as a light yellow oil 3f (2.4g, 5.69mmol, 85percent)., 3405-77-4
3405-77-4 5-Methylisoxazole-3-carboxylic acid 76947, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Zhai, Yangyang; Ma, Yuying; Ma, Fei; Nie, Quandeng; Ren, Xuejiao; Wang, Yaxin; Shang, Luqing; Yin, Zheng; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 559 – 573;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem