With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91252-54-9,Ethyl 5-(tert-butyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.,91252-54-9
Ethyl 5-(tert-butyl)isoxazole-3-carboxylate 17 (1000mg, 5.1mmol) and LiOH (638mg, 15.3mmol) were dissolved in 30mL MeOH and 10mLH2O, respectively. Then the solution was stirred at rt. for 1h. In an ice-cooled bath, 1N Na2SO4 was added, and the mixture was extracted by EtOAc. The organic layer was separated and washed with brine. After drying with anhydrous Na2SO4, the solution was concentrated to give the intermediate 18 (818mg, 95%) as a light yellow oil. 1H NMR (300MHz, CDCl3) delta 10.64 (s, 1H), 6.42 (s, 1H), 1.37 (s, 9H).
As the paragraph descriping shows that 91252-54-9 is playing an increasingly important role.
Reference£º
Article; Liu, Zhiqing; Tian, Bing; Chen, Haiying; Wang, Pingyuan; Brasier, Allan R.; Zhou, Jia; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 450 – 461;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem