With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3405-77-4,5-Methylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Example 1. Compound of formula B, wherein R = (compound 31).To a solution of compound A (25.0 mg, 0.039 mmol), S-methylisoxazole-S-carboxylic acid (5.4 mg, 0.043 mmol) and HATU (16.2 mg, 0.043 mmol) in DMF (0.5 mL) was added diisopropylethylamine (15.0 mg, 0.116 mmol). The reaction mixture was stirred at 25 0C for 16 h and then evaporated under a positive flow of nitrogen. The residue was purified by reverse phase chromatography to give the desired product (20.8 mg, 71percent yield). MS (ESI): m/z = 755.1 [M+H]., 3405-77-4
3405-77-4 5-Methylisoxazole-3-carboxylic acid 76947, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; WO2009/73713; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem