3356-89-6, 5-Chloro-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 5-chloro-3-phenylisoxazole (2) (5 mmol), thiol (10 mmol) and K2CO3 (15 mmol) in DMF (25 mL) was stirred for 36 h at r.t. The reaction mixture was diluted with H2O (40 mL) and extracted with CH2Cl2 (3 ¡Á 20 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel using hexane-EtOAc as the eluent to give the desired compound. 3-Phenyl-5-[(2,2,2-trifluoroethyl)sulfanyl]isoxazole (6a) Yield: 1.28 g (99%); colorless oil. 1H NMR (400 MHz, CDCl3): delta = 7.85-7.75 (m, 2 H), 7.54-7.44 (m, 3 H), 6.69 (s, 1 H), 3.66 (q, J = 9.3 Hz, 2 H). 13 NMR (100 MHz, CDCl3): delta = 163.5, 162.3, 130.4, 129.0, 128.3, 126.8, 124.5 (q, J = 277 Hz), 105.0, 35.3 (q, J = 34.4 Hz). HRMS (ESI): m/z [M + H]+ calcd for C11H9F3NOS: 260.0351; found: 260.0355., 3356-89-6
The synthetic route of 3356-89-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Rostovskii, Nikolai V.; Agafonova, Anastasiya V.; Smetanin, Ilia A.; Novikov, Mikhail S.; Khlebnikov, Alexander F.; Ruvinskaya, Julia O.; Starova, Galina L.; Synthesis; vol. 49; 19; (2017); p. 4478 – 4488;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem